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TPPP3 tubulin polymerization promoting protein family member 3 [ Homo sapiens (human) ]

Gene ID: 51673, updated on 5-Mar-2024

Summary

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Official Symbol
TPPP3provided by HGNC
Official Full Name
tubulin polymerization promoting protein family member 3provided by HGNC
Primary source
HGNC:HGNC:24162
See related
Ensembl:ENSG00000159713 MIM:616957; AllianceGenome:HGNC:24162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p20; CGI-38; TPPP/p20; p25gamma
Summary
Enables tubulin binding activity. Involved in decidualization and microtubule bundle formation. Colocalizes with microtubule bundle and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 89.8), placenta (RPKM 51.0) and 18 other tissues See more
Orthologs
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Genomic context

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See TPPP3 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67389809..67393498, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73184580..73188269, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67423712..67427401, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene RN7SK pseudogene 118 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67454837-67455408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67458128-67458722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67461918-67462452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67462453-67462987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology. Oláh J, et al. Cells, 2022 Sep 27. PMID 36230985, Free PMC Article
  2. The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma. Xiao T, et al. Arch Oral Biol, 2022 Nov. PMID 36058091
  3. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma. Yang Z, et al. Biomed Res Int, 2020. PMID 33083464, Free PMC Article
  4. Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-κB/COX2 signal pathway in breast cancer cell. Ren Q, et al. Cell Biochem Funct, 2020 Aug. PMID 32515139
  5. TPPP3 Promotes Cell Proliferation, Invasion and Tumor Metastasis via STAT3/ Twist1 Pathway in Non-Small-Cell Lung Carcinoma. Li Y, et al. Cell Physiol Biochem, 2018. PMID 30404076

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TPPP3 promote epithelial-mesenchymal transition via Snail1 in glioblastoma.
    Title: TPPP3 promote epithelial-mesenchymal transition via Snail1 in glioblastoma.
  2. Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.
    Title: Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.
  3. The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma.
    Title: The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma.
  4. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma.
    Title: TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma.
  5. Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.
    Title: Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.
  6. Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-kappaB/COX2 signal pathway in breast cancer cell.
    Title: Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-κB/COX2 signal pathway in breast cancer cell.
  7. Data suggest that tubulin polymerization-promoting protein family member 3 (TPPP3) plays a significant role in decidualization.
    Title: Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization.
  8. TPPP3 overexpression enhanced cell proliferation, migration and invasion and regulated the expression of Twist1, suggesting that aberrant expression of TPPP3 could induce a more metastatic phenotype in non-small-cell lung carcinoma.
    Title: TPPP3 Promotes Cell Proliferation, Invasion and Tumor Metastasis via STAT3/ Twist1 Pathway in Non-Small-Cell Lung Carcinoma.
  9. TPPP3 played a crucial role in cell mitosis by regulating centrosomes amplification and/or spindles translocation processes.
    Title: Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.
  10. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
    Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in decidualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo implantation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tubulin polymerization-promoting protein family member 3
Names
brain specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015964.4 → NP_057048.2  tubulin polymerization-promoting protein family member 3

    See identical proteins and their annotated locations for NP_057048.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000691, BQ640401
    Consensus CDS
    CCDS10835.1
    UniProtKB/Swiss-Prot
    Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
    Related
    ENSP00000377529.2, ENST00000393957.7
    Conserved Domains (1) summary
    pfam05517
    Location:11 → 166
    p25-alpha; p25-alpha

  2. NM_016140.4 → NP_057224.2  tubulin polymerization-promoting protein family member 3

    See identical proteins and their annotated locations for NP_057224.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000691, BI754230
    Consensus CDS
    CCDS10835.1
    UniProtKB/Swiss-Prot
    Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
    Related
    ENSP00000290942.5, ENST00000290942.9
    Conserved Domains (1) summary
    pfam05517
    Location:11 → 166
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67389809..67393498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450294.2 → XP_024306062.1  tubulin polymerization-promoting protein family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
    Related
    ENSP00000462435.1, ENST00000564104.5
    Conserved Domains (1) summary
    pfam05517
    Location:11 → 166
    p25-alpha; p25-alpha

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73184580..73188269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BW30.1 GenPept UniProtKB/Swiss-Prot:Q9BW30

Gene LinkOut

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