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HHV4tp2_gp42 BBRF2 [ Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) ]

Gene ID: 5176152, updated on 20-Nov-2023

Summary

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Gene symbol
HHV4tp2_gp42
Gene description
BBRF2
Locus tag
HHV4tp2_gp42
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human herpesvirus 4 type 2 (strain: AG876, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_009334.1 (104490..105326)

NC_009334.1Genomic Context describing neighboring genes Neighboring gene BKRF4 Neighboring gene helicase-primase subunit BBLF4 Neighboring gene BBRF1 Neighboring gene helicase-primase subunit BBLF2/3 Neighboring gene BBRF3 Neighboring gene Alkaline exonuclease Neighboring gene BGLF5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009334.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers. Rowe CL, et al. mBio, 2015 Jan 6. PMID 25564465, Free PMC Article
  2. Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. Kirschner AN, et al. Structure, 2009 Feb 13. PMID 19217393, Free PMC Article
  3. Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. Kirschner AN, et al. J Virol, 2007 Sep. PMID 17581996, Free PMC Article
  4. The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. Chen J, et al. mBio, 2016 Nov 15. PMID 27935841, Free PMC Article
  5. The genome of Epstein-Barr virus type 2 strain AG876. Dolan A, et al. Virology, 2006 Jun 20. PMID 16490228

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study found that the gH cytoplasmic tail domain regulates membrane fusion by altering gp42 and epithelial cell attachment
    Title: The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment.
  2. Cleavage of gp42 generates a soluble functional form that relieves steric hindrance imposed on gHgL by membrane-bound gp42.
    Title: Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers.
  3. The structure of gp42 in its unbound form.
    Title: Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry.
  4. These studies identify key residues of gp42 that are essential for gH/gL binding and membrane fusion activation, providing a nanomolar inhibitor of EBV-mediated membrane fusion.
    Title: Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
BBRF2
Names
ORF42
YP_001129477.1
  • herpesvirus core gene UL7 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009334.1 Reference assembly

    Range
    104490..105326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129477.1 BBRF2 [Human herpesvirus 4 type 2]

    See identical proteins and their annotated locations for YP_001129477.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6Z9, P29882, Q777D5
    UniProtKB/TrEMBL
    A0A0B6VKY2, A0A0C7T9Z6, A0A0C7TJV9, A0A0C7TYN4, A0A0U3SJD6, A0A2S1MPG8, A0A385J9P6, A0A385JAK9, A0A4D6TWT1, K9US56, V5KU48
    Conserved Domains (1) summary
    pfam01677
    Location:28 → 246
    Herpes_UL7; Herpesvirus UL7 like
Protein Accession Links
GenPept Link UniProtKB Link
ABB89257.1

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