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HHV4tp2_gp61 BXLF2 [ Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) ]

Gene ID: 5176171, updated on 18-Aug-2023

Summary

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Gene symbol
HHV4tp2_gp61
Gene description
BXLF2
Locus tag
HHV4tp2_gp61
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human herpesvirus 4 type 2 (strain: AG876, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_009334.1 (129454..131574, complement)

NC_009334.1Genomic Context describing neighboring genes Neighboring gene Capsid triplex subunit 2 Neighboring gene BcLF1 Neighboring gene hypothetical protein Neighboring gene BTRF1 Neighboring gene thymidine kinase Neighboring gene BXRF1 Neighboring gene BVRF1 Neighboring gene BVLF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009334.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells. Möhl BS, et al. J Virol, 2014 Dec. PMID 25231307, Free PMC Article
  2. The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. Chen J, et al. mBio, 2016 Nov 15. PMID 27935841, Free PMC Article
  3. The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion. Chen J, et al. J Virol, 2013 Apr. PMID 23325693, Free PMC Article
  4. A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion. Rowe CL, et al. Virology, 2013 Feb 5. PMID 23200314, Free PMC Article
  5. Epstein-Barr virus glycoprotein gB and gHgL can mediate fusion and entry in trans, and heat can act as a partial surrogate for gHgL and trigger a conformational change in gB. Chesnokova LS, et al. J Virol, 2014 Nov. PMID 25142593, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study found that the gH cytoplasmic tail domain regulates membrane fusion by altering gp42 and epithelial cell attachment
    Title: The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment.
  2. It is suggested that the Gibbs free energy released as a result of the high-affinity interaction of gHgL with an integrin contributes to the activation energy required to cause the refolding of gB from a prefusion to a postfusion conformation.
    Title: Epstein-Barr virus glycoprotein gB and gHgL can mediate fusion and entry in trans, and heat can act as a partial surrogate for gHgL and trigger a conformational change in gB.
  3. Authors conclude that the conserved disulfide bond has a cell type-specific function, since it is important for the binding of gH to epithelial cells initiating epithelial cell fusion but not for fusion with B cells and gp42 binding.
    Title: The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells.
  4. The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion.
    Title: The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion.
  5. investigated whether soluble EBV gH/gL (sgH/gL) functions in fusion; overall, results suggest that domain IV may be required for proper folding and the transmembrane domain and cytoplasmic tail of EBV gH/gL are required for the most efficient fusion
    Title: A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion.
  6. The authors report that integrin alphavbeta5 can also bind to Epstein-Barr virus gHgL and trigger fusion.
    Title: Fusion of Epstein-Barr virus with epithelial cells can be triggered by αvβ5 in addition to αvβ6 and αvβ8, and integrin binding triggers a conformational change in glycoproteins gHgL.
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General gene information

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Homology

General protein information

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Preferred Names
BXLF2
Names
ORF22
YP_001129496.1
  • herpesvirus core gene UL22 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009334.1 Reference assembly

    Range
    129454..131574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129496.1 BXLF2 [Human herpesvirus 4 type 2]

    See identical proteins and their annotated locations for YP_001129496.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q1HVD2, Q3KSQ3
    UniProtKB/TrEMBL
    A0A0C7TU71, G3CKS5
    Conserved Domains (1) summary
    pfam02489
    Location:53 → 702
    Herpes_glycop_H; Herpesvirus glycoprotein H
Protein Accession Links
GenPept Link UniProtKB Link
ABB89276.1

Gene LinkOut

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Molecular Biology Databases
Research Materials