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Tnk2 tyrosine kinase, non-receptor, 2 [ Mus musculus (house mouse) ]

Gene ID: 51789, updated on 21-Apr-2024

Summary

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Official Symbol
Tnk2provided by MGI
Official Full Name
tyrosine kinase, non-receptor, 2provided by MGI
Primary source
MGI:MGI:1858308
See related
Ensembl:ENSMUSG00000022791 AllianceGenome:MGI:1858308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ack; Ack1; Pyk1; Ack-1; Cdgip
Summary
Enables WW domain binding activity. Involved in spermatid development. Located in several cellular components, including endosome; growth cone; and neuronal cell body. Is expressed in several structures, including alimentary system; liver; nervous system; retina; and vibrissa. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 54.9), stomach adult (RPKM 35.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 23.16 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32462699..32502311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32644099..32683493)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7444 Neighboring gene transferrin receptor Neighboring gene STARR-seq mESC enhancer starr_40668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32651205-32651388 Neighboring gene STARR-seq mESC enhancer starr_40671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32668208-32668409 Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_40672 Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways. Jing L, et al. Front Immunol, 2022. PMID 35669783, Free PMC Article
  2. Expression pattern of ACK1 tyrosine kinase during brain development in the mouse. La Torre A, et al. Gene Expr Patterns, 2006 Oct. PMID 16750431
  3. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. Brandao R, et al. FEBS Open Bio, 2021 Jun. PMID 33730447, Free PMC Article
  4. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. Mahajan K, et al. J Biol Chem, 2012 Jun 22. PMID 22566699, Free PMC Article
  5. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Mahajan K, et al. Am J Pathol, 2012 Apr. PMID 22322295, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
    Title: ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
  2. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
    Title: ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
  3. miR-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.
    Title: miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway.
  4. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.
    Title: Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
  5. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.
    Title: Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.
  6. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.
    Title: Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation.
  7. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
    Title: Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
  8. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
    Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
  9. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
    Title: Expression pattern of ACK1 tyrosine kinase during brain development in the mouse.
  10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR.
    Title: Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37479

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables WW domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoophidium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1
Names
Cdc42 GTPase-inhibiting protein
P21cdc42Hs kinase
non-receptor protein tyrosine kinase ACK
tyrosine kinase non-receptor protein 2
NP_001103617.1
NP_001276372.1
NP_001334114.1
NP_058068.2
XP_006522395.1
XP_006522396.1
XP_006522397.1
XP_006522398.1
XP_006522399.1
XP_006522400.1
XP_006522401.1
XP_006522402.1
XP_006522403.1
XP_006522405.1
XP_006522406.1
XP_006522407.1
XP_011244248.1
XP_017172554.1
XP_017172555.1
XP_030105034.1
XP_030105035.1
XP_030105036.1
XP_036015894.1
XP_036015895.1
XP_036015896.1
XP_036015897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110147.1 → NP_001103617.1  activated CDC42 kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001103617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC052421
    Consensus CDS
    CCDS49828.1
    UniProtKB/TrEMBL
    A0A0R4J1L0, D3Z3U5
    Related
    ENSMUSP00000110778.2, ENSMUST00000115125.8
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126 → 385
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:959 → 998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  2. NM_001289443.1 → NP_001276372.1  activated CDC42 kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks part of the 5' coding region, lacks two in-frame exons in the central coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC161755, BB583500, BC052421
    UniProtKB/Swiss-Prot
    O54967
    Conserved Domains (2) summary
    cd14328
    Location:469 → 508
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam11555
    Location:284 → 348
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  3. NM_001347185.1 → NP_001334114.1  activated CDC42 kinase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161755, BC052421
    Consensus CDS
    CCDS84224.1
    UniProtKB/TrEMBL
    D3Z3U7
    Related
    ENSMUSP00000110773.2, ENSMUST00000115120.9

  4. NM_016788.3 → NP_058068.2  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_058068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161755, BQ770866, BU702226, DQ666696
    Consensus CDS
    CCDS37313.1
    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    UniProtKB/TrEMBL
    G3X9X7
    Related
    ENSMUSP00000110777.2, ENSMUST00000115124.9
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:126 → 385
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:976 → 1019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32462699..32502311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317066.3 → XP_017172555.1  activated CDC42 kinase 1 isoform X14

    UniProtKB/TrEMBL
    D3Z3U5, D3Z3U6
    Related
    ENSMUSP00000110776.2, ENSMUST00000115123.9
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:579 → 957
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  2. XM_011245946.1 → XP_011244248.1  activated CDC42 kinase 1 isoform X18

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Conserved Domains (7) summary
    PHA03247
    Location:424 → 802
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:806 → 849
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:836 → 875
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:1 → 217
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:277 → 344
    GTPase_binding; GTPase binding
    pfam11555
    Location:619 → 683
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:225 → 274
    SH3_9; Variant SH3 domain

  3. XM_030249176.1 → XP_030105036.1  activated CDC42 kinase 1 isoform X19

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (6) summary
    PHA03247
    Location:424 → 802
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:804 → 843
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:1 → 217
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:277 → 344
    GTPase_binding; GTPase binding
    pfam11555
    Location:619 → 683
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:225 → 274
    SH3_9; Variant SH3 domain

  4. XM_006522335.1 → XP_006522398.1  activated CDC42 kinase 1 isoform X4

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Related
    ENSMUSP00000159113.2, ENSMUST00000238891.2
    Conserved Domains (8) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618 → 996
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1000 → 1043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1030 → 1069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813 → 877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  5. XM_030249174.2 → XP_030105034.1  activated CDC42 kinase 1 isoform X10

    UniProtKB/TrEMBL
    D3Z3U5
    Conserved Domains (8) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:603 → 981
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:985 → 1028
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1015 → 1054
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798 → 862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  6. XM_036160004.1 → XP_036015897.1  activated CDC42 kinase 1 isoform X17

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (7) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:603 → 981
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:983 → 1022
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798 → 862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  7. XM_036160001.1 → XP_036015894.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Conserved Domains (8) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618 → 996
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1000 → 1043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1030 → 1069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813 → 877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  8. XM_006522339.1 → XP_006522402.1  activated CDC42 kinase 1 isoform X13

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (7) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:618 → 996
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:998 → 1037
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:471 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813 → 877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  9. XM_006522332.5 → XP_006522395.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:626 → 1004
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1008 → 1051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1038 → 1077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  10. XM_006522334.5 → XP_006522397.1  activated CDC42 kinase 1 isoform X3

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:626 → 1016
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1005 → 1049
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1036 → 1075
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  11. XM_006522338.5 → XP_006522401.1  activated CDC42 kinase 1 isoform X11

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:626 → 1004
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  12. XM_006522336.5 → XP_006522399.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A5F8MPC4, D3Z3U5
    Related
    ENSMUSP00000158905.2, ENSMUST00000238856.2
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:993 → 1036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1023 → 1062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  13. XM_036160002.1 → XP_036015895.1  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    D3Z3U5
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 1001
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:990 → 1034
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1021 → 1060
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  14. XM_030249175.2 → XP_030105035.1  activated CDC42 kinase 1 isoform X15

    UniProtKB/TrEMBL
    A0A5F8MPM0, A0A5F8MQ87
    Related
    ENSMUSP00000159023.2, ENSMUST00000238806.2
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  15. XM_006522333.5 → XP_006522396.1  activated CDC42 kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    O54967, Q0Z844, Q8C2U0, Q8K0K4
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:626 → 1004
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1008 → 1051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1038 → 1077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  16. XM_036160003.1 → XP_036015896.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:626 → 1004
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  17. XM_017317065.3 → XP_017172554.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    D3Z3U5
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:993 → 1036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1023 → 1062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  18. XM_006522337.5 → XP_006522400.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    D3Z3U5
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 1001
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:990 → 1034
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1021 → 1060
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  19. XM_006522340.5 → XP_006522403.1  activated CDC42 kinase 1 isoform X16

    UniProtKB/TrEMBL
    A0A5F8MQ87
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:611 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  20. XM_006522342.5 → XP_006522405.1  activated CDC42 kinase 1 isoform X20

    Conserved Domains (6) summary
    PHA03247
    Location:186 → 565
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:568 → 611
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:598 → 637
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:39 → 106
    GTPase_binding; GTPase binding
    pfam11555
    Location:381 → 445
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl17036
    Location:6 → 36
    SH3; Src Homology 3 domain superfamily

  21. XM_006522344.1 → XP_006522407.1  activated CDC42 kinase 1 isoform X21

    See identical proteins and their annotated locations for XP_006522407.1

    Conserved Domains (5) summary
    PHA03247
    Location:104 → 483
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:486 → 529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516 → 555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:1 → 24
    GTPase_binding; GTPase binding
    pfam11555
    Location:299 → 363
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  22. XM_006522343.1 → XP_006522406.1  activated CDC42 kinase 1 isoform X21

    See identical proteins and their annotated locations for XP_006522406.1

    Conserved Domains (5) summary
    PHA03247
    Location:104 → 483
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:486 → 529
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:516 → 555
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    pfam09027
    Location:1 → 24
    GTPase_binding; GTPase binding
    pfam11555
    Location:299 → 363
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54967.2 GenPept UniProtKB/Swiss-Prot:O54967

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