Tmem38b transmembrane protein 38B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem38bprovided by MGI
Official Full Name: transmembrane protein 38Bprovided by MGI
Primary source: MGI:MGI:1098718
See related: Ensembl:ENSMUSG00000028420 AllianceGenome:MGI:1098718
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mg33b; TRIC-B; D4Ertd89e; 1600017F22Rik
Summary: Predicted to enable potassium channel activity. Acts upstream of or within several processes, including cellular response to caffeine; lung development; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 7.5), liver adult (RPKM 7.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B2; 4 28.76 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (53825988..53862019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (53825988..53862019)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice.
Title: Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice.
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study.
Title: Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study.
CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.
Title: CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.
The role of TRIC-A and TRIC-B channels in skeletal muscle sarcoplasmic reticulum channels is reported.
Title: Enhanced activity of multiple TRIC-B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents.
TRIC-B function is essential to support the production and release of large amounts of collagen by osteoblasts, which is necessary for bone mineralization
Title: Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
This mini-review focuses on the essential role of TRIC-B channels in bone ossification.
Title: TRIC-B Mutations Causing Osteogenesis Imperfecta.
Study found that a simplified, linear, six-state gating model best encompasses the complexity of the subconductance gating behavior of TRIC-B channels
Title: Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach.
Rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models.
Title: TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.
TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells.
Title: Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis.
TRIC-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth. In mutant neonates, the deflated lungs exhibited severe histological defects, and alveolar type II epithelial cells displayed ultrastructural abnormalities.
Title: Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126257 (e-PCR)
- UniSTS:162965

NoName (e-PCR)
- UniSTS:234923

NoName (e-PCR)
- UniSTS:234924

RH137236 (e-PCR)
- UniSTS:219324

D4Mit240 (e-PCR), detects polymorphism
- UniSTS:130027

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to caffeine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix constituent secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within secretion by lung epithelial cell involved in lung growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trimeric intracellular cation channel type B

Names: Mitsugumin33B; TRICB; mitsugumin-33B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028053.2 → NP_082329.1 trimeric intracellular cation channel type B

See identical proteins and their annotated locations for NP_082329.1

Status: VALIDATED

Source sequence(s)

AK005479, AK136131, AK150377, BY138283

Consensus CDS

CCDS18193.1

UniProtKB/Swiss-Prot

A2AQG4, Q3U6M4, Q3UBM6, Q3UWS8, Q9DAV9

Related

ENSMUSP00000030127.7, ENSMUST00000030127.13

Conserved Domains (1) summary

pfam05197
Location:39 → 222

TRIC; TRIC channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

53825988..53862019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538083.2 → XP_006538146.1 trimeric intracellular cation channel type B isoform X1

Conserved Domains (1) summary

pfam05197
Location:1 → 106

TRIC; TRIC channel