Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgtaprovided by MGI
Official Full Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, alphaprovided by MGI
Primary source: MGI:MGI:1098703
See related: Ensembl:ENSMUSG00000004937 AllianceGenome:MGI:1098703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgt; Stg; D10Ertd190e; 5330427H01Rik
Summary: Predicted to enable several functions, including BAT3 complex binding activity; protein dimerization activity; and protein self-association. Predicted to be involved in several processes, including establishment of protein localization to membrane; regulation of ER-associated ubiquitin-dependent protein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skin. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 191.2), mammary gland adult (RPKM 106.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80879905..80896105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81044071..81060271, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SGTA associates with intracellular aggregates in neurodegenerative diseases.
Title: SGTA associates with intracellular aggregates in neurodegenerative diseases.
In conclusion, this thorough investigation of SGTA-null mutation reports a mild phenotype of reduced body size.
Title: Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.
the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation.
Title: Binding of SGTA to Rpn13 selectively modulates protein quality control.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126405 (e-PCR)
- UniSTS:163113

RH135919 (e-PCR)
- UniSTS:209916

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BAT3 complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small glutamine-rich tetratricopeptide repeat-containing protein alpha

Names: alpha-SGT; small glutamine-rich tetratricopeptide repeat (TPR) containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358549.2 → NP_001345478.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

Status: VALIDATED

Source sequence(s)

AC152500

Consensus CDS

CCDS35990.1

UniProtKB/Swiss-Prot

Q8BGA6, Q8BJU0, Q99L52

Conserved Domains (3) summary

sd00006
Location:92 → 120

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerisation domain of SGTA

cl26005
Location:106 → 212

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
NM_001358550.2 → NP_001345479.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC152500

Consensus CDS

CCDS88056.1

UniProtKB/TrEMBL

Q3TN35

Related

ENSMUSP00000151949.2, ENSMUST00000218208.2

Conserved Domains (3) summary

PLN03088
Location:105 → 211

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:91 → 119

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerization domain of SGTA
NM_001428937.1 → NP_001415866.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

Status: VALIDATED

Source sequence(s)

AC152500
NM_001428938.1 → NP_001415867.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC152500
NM_001428939.1 → NP_001415868.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC152500
NM_024499.3 → NP_078775.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

See identical proteins and their annotated locations for NP_078775.1

Status: VALIDATED

Source sequence(s)

AC152500

Consensus CDS

CCDS35990.1

UniProtKB/Swiss-Prot

Q8BGA6, Q8BJU0, Q99L52

Related

ENSMUSP00000005067.6, ENSMUST00000005067.6

Conserved Domains (3) summary

sd00006
Location:92 → 120

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerisation domain of SGTA

cl26005
Location:106 → 212

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RNA

NR_190542.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC152500

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80879905..80896105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513877.2 → XP_006513940.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

UniProtKB/TrEMBL

Q3TN35

Conserved Domains (3) summary

PLN03088
Location:105 → 211

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:91 → 119

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerization domain of SGTA
XM_030245176.2 → XP_030101036.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X2

Conserved Domains (2) summary

PLN03088
Location:4 → 110

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:23 → 53

TPR; TPR repeat [structural motif]