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NR4A1 nuclear receptor subfamily 4 group A member 1 [ Bos taurus (cattle) ]

Gene ID: 528390, updated on 8-Jul-2021

Summary

Official Symbol
NR4A1provided by VGNC
Official Full Name
nuclear receptor subfamily 4 group A member 1provided by VGNC
Primary source
VGNC:VGNC:32245
See related
BGD:BT24749; Ensembl:ENSBTAG00000000507
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

See NR4A1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 5 NC_037332.1 (27822914..27839686, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 5 AC_000162.1 (27977000..27993693, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104972390 Neighboring gene autophagy related 101 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene activin A receptor type 1B

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to corticotropin-releasing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075911.1NP_001069379.1  nuclear receptor subfamily 4 group A member 1

    See identical proteins and their annotated locations for NP_001069379.1

    Status: PROVISIONAL

    Source sequence(s)
    BT026269
    UniProtKB/Swiss-Prot
    Q0V8F0
    Related
    ENSBTAP00000000648.4, ENSBTAT00000000648.5
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    27822914..27839686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206220.4XP_005206277.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005206277.1

    UniProtKB/Swiss-Prot
    Q0V8F0
    Related
    ENSBTAP00000068549.1, ENSBTAT00000084818.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_005206221.1XP_005206278.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005206278.1

    UniProtKB/Swiss-Prot
    Q0V8F0
    Related
    ENSBTAP00000057165.1, ENSBTAT00000076548.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_024991837.1XP_024847605.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Related
    ENSBTAP00000064607.1, ENSBTAT00000082220.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  4. XM_005206219.3XP_005206276.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005206276.1

    UniProtKB/Swiss-Prot
    Q0V8F0
    Related
    ENSBTAP00000073929.1, ENSBTAT00000071983.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  5. XM_010804908.3XP_010803210.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_010803210.1

    UniProtKB/Swiss-Prot
    Q0V8F0
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
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