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Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) [ Mus musculus (house mouse) ]

Gene ID: 52858, updated on 23-Jun-2021

Summary

Official Symbol
Cdiptprovided by MGI
Official Full Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)provided by MGI
Primary source
MGI:MGI:105491
See related
Ensembl:ENSMUSG00000030682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pis; Pis1; D7Bwg0575e; 9530042F15Rik
Expression
Ubiquitous expression in large intestine adult (RPKM 67.2), duodenum adult (RPKM 64.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cdipt in Genome Data Viewer
Location:
7 F3; 7 69.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126575630..126579671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126976458..126980499)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134119863..134124015)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like 2 Neighboring gene CDIP transferase, opposite strand Neighboring gene major vault protein Neighboring gene PAXIP1 associated glutamate rich protein 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables alcohol binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Names
PI synthase
phosphatidylinositol synthase
ptdIns synthase
NP_001334585.1
NP_001366189.1
NP_080914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347656.2NP_001334585.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS85418.1
    UniProtKB/TrEMBL
    A0A0U1RPV3
    Related
    ENSMUSP00000146137.2, ENSMUST00000206346.2
  2. NM_001379260.1NP_001366189.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC122863
    Conserved Domains (1) summary
    pfam01066
    Location:1072
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  3. NM_026638.4NP_080914.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1

    See identical proteins and their annotated locations for NP_080914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS21853.1
    UniProtKB/Swiss-Prot
    Q8VDP6
    Related
    ENSMUSP00000032920.4, ENSMUST00000032920.5
    Conserved Domains (1) summary
    pfam01066
    Location:1072
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126575630..126579671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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