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Atp2a3 ATPase, Ca++ transporting, ubiquitous [ Mus musculus (house mouse) ]

Gene ID: 53313, updated on 21-Apr-2024

Summary

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Official Symbol
Atp2a3provided by MGI
Official Full Name
ATPase, Ca++ transporting, ubiquitousprovided by MGI
Primary source
MGI:MGI:1194503
See related
Ensembl:ENSMUSG00000020788 AllianceGenome:MGI:1194503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Serca3; SERCA3b
Summary
Enables calcium ion binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; calcium ion transport from cytosol to endoplasmic reticulum; and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to act upstream of or within calcium ion transport. Located in endoplasmic reticulum. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 314.1), thymus adult (RPKM 123.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 45.0 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72851995..72883869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72961169..72993043)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34704 Neighboring gene predicted gene, 34793 Neighboring gene STARR-positive B cell enhancer ABC_E7013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation. Feng M, et al. Circ Res, 2020 Sep 11. PMID 32588751
  2. Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores. Elaïb Z, et al. Blood, 2016 Aug 25. PMID 27301859
  3. Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception. Iguchi N, et al. PLoS One, 2011. PMID 21829714, Free PMC Article
  4. SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Arredouani A, et al. Diabetes, 2002 Nov. PMID 12401716
  5. Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. Kao J, et al. Am J Physiol, 1999 Aug. PMID 10444520

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
    Title: NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
  2. SERCA3-dependent Ca(2+) stores control a specific ADP secretion pathway.
    Title: Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores.
  3. ANP counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP/GC-A (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload.
    Title: Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.
  4. This study evaluated the role of SERCA2b and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin secretion.
    Title: Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.
  5. Ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells
    Title: SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.
  6. identification of promoter region and binding site for Ets-1 in mouse SERCA3
    Title: Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1.
  7. regulation in insulin-secreting beta-cells by insulin receptor substrate 1
    Title: Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells.
  8. IRS-1 modulation of insulin secretion is associated with Ca(2+) signaling and expression of SERCA-2b and -3 genes in pancreatic islets. Direct link between insulin resistance and defective insulin secretion.
    Title: Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport from cytosol to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Names
SR Ca(2+)-ATPase 3
calcium pump 3
sarco /endoplasmic reticulum Ca2+ -ATPase
sarcoendoplasmic reticulum Ca2+ ATPase type 3
NP_001156808.1
NP_001156809.1
NP_058025.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163336.1 → NP_001156808.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

    See identical proteins and their annotated locations for NP_001156808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK089487, AK152999, AK155904, BY549777
    Consensus CDS
    CCDS48843.1
    UniProtKB/Swiss-Prot
    O70625, Q64517, Q64518, Q8VD16
    UniProtKB/TrEMBL
    Q3U1K2, Q8R0X5
    Related
    ENSMUSP00000104125.3, ENSMUST00000108485.9
    Conserved Domains (1) summary
    cd02083
    Location:5 → 989
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

  2. NM_001163337.1 → NP_001156809.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK089487, AK152999, AK155904, AL670399, BY549777, U49393
    Consensus CDS
    CCDS48842.1
    UniProtKB/TrEMBL
    E9Q559, Q3U1K2
    Related
    ENSMUSP00000127036.2, ENSMUST00000163326.8
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  3. NM_016745.3 → NP_058025.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

    See identical proteins and their annotated locations for NP_058025.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK089487, AK152999, AK155904, BY549777, U49393
    Consensus CDS
    CCDS24991.1
    UniProtKB/TrEMBL
    B1ATS5
    Related
    ENSMUSP00000021142.8, ENSMUST00000021142.8
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72851995..72883869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64518.4 GenPept UniProtKB/Swiss-Prot:Q64518

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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