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Usp2 ubiquitin specific peptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 53376, updated on 5-Mar-2024

Summary

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Official Symbol
Usp2provided by MGI
Official Full Name
ubiquitin specific peptidase 2provided by MGI
Primary source
MGI:MGI:1858178
See related
Ensembl:ENSMUSG00000032010 AllianceGenome:MGI:1858178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubp41; B930035K21Rik
Summary
Enables identical protein binding activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in several cellular components, including cell cortex; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; integumental system; and reproductive system. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.3), heart adult (RPKM 6.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Usp2 in Genome Data Viewer
Location:
9 A5.1; 9 24.53 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (43978318..44006924)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44067021..44095627)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39323 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:43828190-43828343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:43851446-43851555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:43855184-43855482 Neighboring gene thymus cell antigen 1, theta Neighboring gene STARR-positive B cell enhancer ABC_E1383 Neighboring gene predicted gene, 39325 Neighboring gene predicted gene, 38444 Neighboring gene C1q and tumor necrosis factor related protein 5 Neighboring gene STARR-seq mESC enhancer starr_23954 Neighboring gene membrane frizzled-related protein Neighboring gene ring finger protein 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm. Hashimoto M, et al. Cell Mol Life Sci, 2021 Mar. PMID 33104844
  2. Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts. Hashimoto M, et al. Physiol Rep, 2019 Jul. PMID 31353872, Free PMC Article
  3. 3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity. Yang H, et al. Mol Nutr Food Res, 2017 Oct. PMID 28586165
  4. Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. Pouly D, et al. Am J Physiol Renal Physiol, 2013 Jul 1. PMID 23552861
  5. Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility. Bedard N, et al. Biol Reprod, 2011 Sep. PMID 21543767, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.
    Title: USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.
  2. USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
    Title: USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
  3. Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.
    Title: Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.
  4. Behavioral phenotyping of mice lacking the deubiquitinase USP2.
    Title: Behavioral phenotyping of mice lacking the deubiquitinase USP2.
  5. Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm.
    Title: Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm.
  6. USP2 knockdown causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.
    Title: Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.
  7. These findings have characterized an essential role of USP2a as a potential target for treatment of metastatic cancers.
    Title: USP2a Supports Metastasis by Tuning TGF-β Signaling.
  8. 3,3'-Diindolylmethane directly inhibits USP2 deubiquitinase activity in 3T3-L1 pre-adipocytes.
    Title: 3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.
  9. Usp2 is required for the PTH1-34-induced proliferation of osteoblasts
    Title: PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific Peptidase 2 (Usp2) Expression.
  10. Usp2 is a clock output effector related to bodily Ca2+ homeostasis, a feature that is conserved across evolution.
    Title: USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 2
Names
41 kDa ubiquitin-specific protease
deubiquitinating enzyme 2
ubiquitin specific protease 2
ubiquitin thioesterase 2
ubiquitin thiolesterase 2
ubiquitin-specific-processing protease 2
NP_001394747.1
NP_001394748.1
NP_001394749.1
NP_001394750.1
NP_001394751.1
NP_001394752.1
NP_001394753.1
NP_001394754.1
NP_001394755.1
NP_001394756.1
NP_058088.2
NP_932759.1
NP_932760.2
XP_006510549.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407818.1 → NP_001394747.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    Status: VALIDATED

    Source sequence(s)
    AC148328
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87
    Related
    ENSMUSP00000135018.2, ENSMUST00000177054.8

  2. NM_001407819.1 → NP_001394748.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    Status: VALIDATED

    Source sequence(s)
    AC148328
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87

  3. NM_001407820.1 → NP_001394749.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    Status: VALIDATED

    Source sequence(s)
    AC148328
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87

  4. NM_001407821.1 → NP_001394750.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    Status: VALIDATED

    Source sequence(s)
    AC148328
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87

  5. NM_001407822.1 → NP_001394751.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    Status: VALIDATED

    Source sequence(s)
    AC148328
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87

  6. NM_001407823.1 → NP_001394752.1  ubiquitin carboxyl-terminal hydrolase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC148328
    Related
    ENSMUSP00000135482.2, ENSMUST00000176416.8

  7. NM_001407824.1 → NP_001394753.1  ubiquitin carboxyl-terminal hydrolase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC148328

  8. NM_001407825.1 → NP_001394754.1  ubiquitin carboxyl-terminal hydrolase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC148328

  9. NM_001407826.1 → NP_001394755.1  ubiquitin carboxyl-terminal hydrolase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC148328

  10. NM_001407827.1 → NP_001394756.1  ubiquitin carboxyl-terminal hydrolase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC148328

  11. NM_016808.2 → NP_058088.2  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    See identical proteins and their annotated locations for NP_058088.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same protein (isoform Usp2-69).
    Source sequence(s)
    AC148328, AY255640, BE991773, BY097860
    Consensus CDS
    CCDS23094.1
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87
    Related
    ENSMUSP00000110479.3, ENSMUST00000114830.9
    Conserved Domains (1) summary
    pfam00443
    Location:281 → 610
    UCH; Ubiquitin carboxyl-terminal hydrolase

  12. NM_198091.2 → NP_932759.1  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-45

    See identical proteins and their annotated locations for NP_932759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 3. The resulting protein (isoform Usp2-45) has a distinct N-terminus and is shorter compared to isoform Usp2-69.
    Source sequence(s)
    AC148328, AY255637, BE991773, BY237727
    Consensus CDS
    CCDS23095.1
    UniProtKB/Swiss-Prot
    O88623
    Related
    ENSMUSP00000070264.8, ENSMUST00000065461.9
    Conserved Domains (1) summary
    pfam00443
    Location:58 → 387
    UCH; Ubiquitin carboxyl-terminal hydrolase

  13. NM_198092.2 → NP_932760.2  ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69

    See identical proteins and their annotated locations for NP_932760.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer protein (isoform Usp2-69). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC148328, AY255638, BB617020, BE991773
    Consensus CDS
    CCDS23094.1
    UniProtKB/Swiss-Prot
    O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87
    Related
    ENSMUSP00000034508.8, ENSMUST00000034508.14
    Conserved Domains (1) summary
    pfam00443
    Location:281 → 610
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    43978318..44006924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510486.5 → XP_006510549.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88623.3 GenPept UniProtKB/Swiss-Prot:O88623

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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