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Htatip2 HIV-1 Tat interactive protein 2 [ Mus musculus (house mouse) ]

Gene ID: 53415, updated on 5-Mar-2024

Summary

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Official Symbol
Htatip2provided by MGI
Official Full Name
HIV-1 Tat interactive protein 2provided by MGI
Primary source
MGI:MGI:1859271
See related
Ensembl:ENSMUSG00000039745 AllianceGenome:MGI:1859271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cc3; Tip30
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in import into nucleus and regulation of angiogenesis. Predicted to act upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm. Is expressed in heart and limb. Orthologous to human HTATIP2 (HIV-1 Tat interactive protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 12.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B4; 7 31.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (49408761..49423748)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (49759045..49774000)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45985 Neighboring gene STARR-seq mESC enhancer starr_18912 Neighboring gene predicted gene, 32962 Neighboring gene STARR-positive B cell enhancer ABC_E11738 Neighboring gene predicted gene, 45986 Neighboring gene protein arginine N-methyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_18916 Neighboring gene STARR-seq mESC enhancer starr_18918 Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1. Yang W, et al. Glia, 2015 Apr. PMID 25530119
  2. Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors. Zhang C, et al. Cancer Res, 2010 Dec 15. PMID 21159643, Free PMC Article
  3. Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland. Pecha J, et al. Oncogene, 2007 Nov 22. PMID 17533366
  4. Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Chen F, et al. Cell Death Dis, 2014 May 22. PMID 24853420, Free PMC Article
  5. TIP30 deficiency increases susceptibility to tumorigenesis. Ito M, et al. Cancer Res, 2003 Dec 15. PMID 14695192

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression or knockdown of Htatip2 in hepatocytes affected fatty acid storage and oxidation, consistent with a novel role in mediating the differential effects of PKC isoforms on lipid metabolism.
    Title: Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism.
  2. Data suggest that TIP30 plays a negative regulatory role in oligodendroglial differentiation.
    Title: TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1.
  3. TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage, and loss of it promotes expansion of ER(+) luminal progenitors and mature cells and ER(+) mammary tumorigenesis.
    Title: Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.
  4. TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung.
    Title: TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice.
  5. TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes.
    Title: A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.
  6. Results suggest that Tip30 is an intrinsic and negative regulator of MEC proliferation partly through the inhibition of Wisp2 and Igf-1 expression, and its absence in the mammary gland may predispose MECs to neoplastic transformation.
    Title: Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oxidoreductase HTATIP2
Names
HIV-1 tat interactive protein 2, 30 kDa homolog
HIV-1 tat interactive protein 2, homolog
tat-interacting protein 30 kDa
NP_001139521.1
NP_001139522.1
NP_001139524.1
NP_001139525.1
NP_058561.2
XP_006541052.1
XP_030098630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146049.1 → NP_001139521.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001139521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK144837, AW121187, BY292123
    Consensus CDS
    CCDS52260.1
    UniProtKB/Swiss-Prot
    Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
    Related
    ENSMUSP00000082374.6, ENSMUST00000085272.7
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  2. NM_001146050.1 → NP_001139522.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001139522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK151254, AW121187, BB575839, CB593552
    Consensus CDS
    CCDS52260.1
    UniProtKB/Swiss-Prot
    Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  3. NM_001146052.1 → NP_001139524.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001139524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK008630, AK151254, AW121187, CB318388
    Consensus CDS
    CCDS52260.1
    UniProtKB/Swiss-Prot
    Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  4. NM_001146053.1 → NP_001139525.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001139525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AK151254, AW121187, BB575839
    Consensus CDS
    CCDS52260.1
    UniProtKB/Swiss-Prot
    Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  5. NM_016865.3 → NP_058561.2  oxidoreductase HTATIP2 isoform a

    See identical proteins and their annotated locations for NP_058561.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK151254, AW121187, BY292123
    Consensus CDS
    CCDS85310.1
    UniProtKB/TrEMBL
    Q3U816
    Related
    ENSMUSP00000146858.2, ENSMUST00000207895.2
    Conserved Domains (2) summary
    cd05250
    Location:52 → 264
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    COG0702
    Location:54 → 226
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    49408761..49423748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242770.2 → XP_030098630.1  oxidoreductase HTATIP2 isoform X2

    Conserved Domains (1) summary
    cd05250
    Location:19 → 219
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  2. XM_006540989.1 → XP_006541052.1  oxidoreductase HTATIP2 isoform X1

    Conserved Domains (1) summary
    cd05250
    Location:52 → 252
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2G9.3 GenPept UniProtKB/Swiss-Prot:Q9Z2G9

Gene LinkOut

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