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lectin-46Cb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53522, updated on 29-Dec-2023

Summary

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Official Symbol
lectin-46Cbprovided by FlyBase
Primary source
FLYBASE:FBgn0040092
Locus tag
Dmel_CG1652
See related
AllianceGenome:FB:FBgn0040092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 007330B; AC007330b; CG1652; Dmel\CG1652; Lectin-46Cb; lectin46Cb
Summary
Predicted to enable galactose binding activity. Involved in protein localization; regulation of female receptivity, post-mating; and sperm competition. Located in extracellular space. Is expressed in adult head and organism. Orthologous to several human genes including CLEC17A (C-type lectin domain containing 17A); CLEC6A (C-type lectin domain containing 6A); and CLEC9A (C-type lectin domain containing 9A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
46B4-46B4; 2-61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9815510..9816600)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5703015..5704105)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44208 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lectin-46Ca Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex peptide is required for the efficient release of stored sperm in mated Drosophila females. Avila FW, et al. Genetics, 2010 Oct. PMID 20679516, Free PMC Article
  2. The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility. Maeda RK, et al. PLoS Genet, 2018 Jul. PMID 30011265, Free PMC Article
  3. A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila. Ram KR, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706411, Free PMC Article
  4. Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females. Misra S, et al. Elife, 2020 Jul 16. PMID 32672537, Free PMC Article
  5. Acp36DE is required for uterine conformational changes in mated Drosophila females. Avila FW, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19805225, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables galactose binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of female receptivity, post-mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
involved_in sperm competition IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
lectin-46Cb
Names
CG1652-PB
lectin 46cb
lectin-46Cb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9815510..9816600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169631.1 → NP_001163102.1  lectin-46Cb [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JY62
    Conserved Domains (1) summary
    cd00037
    Location:38 → 155
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JY62 Q7JY62

Gene LinkOut

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