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Dctn3 dynactin 3 [ Mus musculus (house mouse) ]

Gene ID: 53598, updated on 5-Mar-2024

Summary

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Official Symbol
Dctn3provided by MGI
Official Full Name
dynactin 3provided by MGI
Primary source
MGI:MGI:1859251
See related
Ensembl:ENSMUSG00000028447 AllianceGenome:MGI:1859251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p24
Summary
Acts upstream of or within microtubule-based process. Part of dynactin complex. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 56.9), CNS E14 (RPKM 43.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 21.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41714798..41723213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41714798..41723163, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene STARR-seq mESC enhancer starr_10037 Neighboring gene STARR-positive B cell enhancer ABC_E11235 Neighboring gene ribonuclease P/MRP 25 subunit-like Neighboring gene AT-rich interaction domain 3C Neighboring gene STARR-positive B cell enhancer ABC_E2689 Neighboring gene sigma non-opioid intracellular receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and molecular characterization of the p24 dynactin light chain. Pfister KK, et al. Cell Motil Cytoskeleton, 1998. PMID 9786090
  2. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
  3. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article
  4. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule-based process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dynactin complex ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynactin subunit 3
Names
dynactin light chain (P24)
dynactin light chain p24
p24 dynactin light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159565.1 → NP_001153037.1  dynactin subunit 3 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several in-frame segments in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AK011840, AV493721, BY141790
    Consensus CDS
    CCDS51143.1
    UniProtKB/TrEMBL
    E9Q919
    Related
    ENSMUSP00000130988.2, ENSMUST00000171641.2
    Conserved Domains (1) summary
    pfam07426
    Location:10 → 137
    Dynactin_p22; Dynactin subunit p22

  2. NM_016890.4 → NP_058586.3  dynactin subunit 3 isoform A

    See identical proteins and their annotated locations for NP_058586.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK011840, BY141790
    Consensus CDS
    CCDS18069.1
    UniProtKB/Swiss-Prot
    Q9CR43, Q9D039, Q9Z0Y1
    Related
    ENSMUSP00000030158.5, ENSMUST00000030158.11
    Conserved Domains (1) summary
    pfam07426
    Location:10 → 170
    Dynactin_p22; Dynactin subunit p22

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41714798..41723213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164239.1 → XP_036020132.1  dynactin subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam07426
    Location:10 → 117
    Dynactin_p22; Dynactin subunit p22
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0Y1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0Y1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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