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Ear7 eosinophil-associated, ribonuclease A family, member 7 [ Mus musculus (house mouse) ]

Gene ID: 53873, updated on 7-Sep-2023

Summary

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Official Symbol
Ear7provided by MGI
Official Full Name
eosinophil-associated, ribonuclease A family, member 7provided by MGI
Primary source
MGI:MGI:1858205
See related
AllianceGenome:MGI:1858205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mR7
Summary
Enables ribonuclease activity. Acts upstream of or within RNA metabolic process. Predicted to be located in secretory granule. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 14

Bibliography

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Related articles in PubMed

  1. Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo. Nitto T, et al. Genes Immun, 2004 Dec. PMID 15526002
  2. Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities. Attery A, et al. Int J Biol Macromol, 2017 Jan. PMID 27765572
  3. Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Cormier SA, et al. Mamm Genome, 2001 May. PMID 11331942
  4. Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Larson KA, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901588, Free PMC Article
  5. Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice. Singhania NA, et al. J Mol Evol, 1999 Dec. PMID 10594173

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
    Title: Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in secretory granule TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
eosinophil-associated, ribonuclease A family, member 7
Names
eosinophil-associated ribonuclease 7
murine ribonuclease 7
NP_059081.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017385.1 → NP_059081.1  eosinophil-associated, ribonuclease A family, member 7 precursor

    See identical proteins and their annotated locations for NP_059081.1

    Status: PROVISIONAL

    Source sequence(s)
    AY324806
    UniProtKB/TrEMBL
    Q9R126
    Conserved Domains (1) summary
    pfam00074
    Location:30 → 152
    RnaseA; Pancreatic ribonuclease
Nucleotide Protein Strain
Heading Accession and Version

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