Semg1 semenogelin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Semg1provided by MGI
Official Full Name: semenogelin 1provided by MGI
Primary source: MGI:MGI:1858275
See related: Ensembl:ENSMUSG00000040132 AllianceGenome:MGI:1858275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Svs2; SvsII
Summary: Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within fertilization and sperm capacitation. Located in acrosomal vesicle. Is expressed in alimentary system; bladder; and male reproductive gland or organ. Orthologous to several human genes including SEMG1 (semenogelin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2 H3; 2 84.82 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164077849..164080261, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164235929..164238341, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.
Title: Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.
Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract.
Title: Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract.
SVS3, SVS4, SVS5, and SVS6 do not function in the protection of sperm against a uterine immune attack in the absence of SVS2. Thus, Svs2 is the critical gene in the seminal vesicle proteins gene cluster.
Title: Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.
SVS2 keeps sterols on the sperm plasma membrane and plays a key role in unlocking sperm capacitation in vivo.
Title: Seminal vesicle secretion 2 acts as a protectant of sperm sterols and prevents ectopic sperm capacitation in mice.
Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
Title: Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
the fertility of ejaculated sperm is associated with SVS2 distribution in the female reproductive tract, SVS2 functions as a decapacitation factor for mouse sperm.
Title: Semen-coagulating protein, SVS2, in mouse seminal plasma controls sperm fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Markers

BB115391 (e-PCR)
- UniSTS:185514

NoName (e-PCR)
- UniSTS:487861

X91270 (e-PCR)
- UniSTS:125884

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fertilization	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: semenogelin I

Names: semenoclotin; seminal vesicle protein, secretion 2; seminal vesicle secretory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.