GZMA granzyme A [Bos taurus (cattle)] - Gene

Summary

Gene symbol: GZMA
Gene description: granzyme A
See related: BGD:BT14165; Ensembl:ENSBTAG00000021958
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (24009813..24018787, complement)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.
Title: Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: granzyme A

Names: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

NP_001092565.1

EC 3.4.21.78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099095.1 → NP_001092565.1 granzyme A precursor

See identical proteins and their annotated locations for NP_001092565.1

Status: PROVISIONAL

Source sequence(s)

BC142336

UniProtKB/TrEMBL

A5PK33, F6QZF5

Related

ENSBTAP00000029273.6, ENSBTAT00000029273.6

Conserved Domains (2) summary

smart00020
Location:27 → 251

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:28 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...