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PPIL3 peptidylprolyl isomerase like 3 [ Homo sapiens (human) ]

Gene ID: 53938, updated on 3-Apr-2024

Summary

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Official Symbol
PPIL3provided by HGNC
Official Full Name
peptidylprolyl isomerase like 3provided by HGNC
Primary source
HGNC:HGNC:9262
See related
Ensembl:ENSG00000240344 MIM:615811; AllianceGenome:HGNC:9262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPJ
Summary
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q33.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (200870907..200889291, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201354357..201372783, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201735630..201753800, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5577 Neighboring gene RNA, 5S ribosomal pseudogene 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16965 Neighboring gene CDC like kinase 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:201753436-201754635 Neighboring gene RNA, U6 small nuclear 312, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16968 Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene RNA, U6 small nuclear 762, pseudogene Neighboring gene origin recognition complex subunit 2 Neighboring gene OCT4 hESC enhancer GRCh37_chr2:201799831-201800332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16969 Neighboring gene uncharacterized LOC105373835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma. Gong Z, et al. Anticancer Res, 2017 Aug. PMID 28739742
  2. Biochemical Features of Recombinant Human Cyclophilin J. Chen J, et al. Anticancer Res, 2016 Mar. PMID 26977013
  3. Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. Chen J, et al. PLoS One, 2015. PMID 26020957, Free PMC Article
  4. Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J. Hu H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Feb 1. PMID 16510998, Free PMC Article
  5. cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene. Qi ZY, et al. Chin Med J (Engl), 2005 May 20. PMID 15989758

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclophilin J expression was up-regulated in gastric carcinoma compared to normal gastric tissues.
    Title: Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma.
  2. CYPJ structurally resembles CYPA. It is sensitive to inhibition by CsA and plays a role in regulating cell growth, proliferation, and apoptosis.
    Title: Biochemical Features of Recombinant Human Cyclophilin J.
  3. Suppression of CYPJ could repress the growth of HCC, which makes CYPJ a potential target for the development of new strategies to treat this malignancy.
    Title: Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins.
    Title: Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells.
  6. The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma.
    Title: cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene.
  7. Human cyclophilin J, a new member of the cyclophilin family, has been expressed and crystallized.
    Title: Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase-like 3
Names
PPIase
PPIase-like protein 3
cyclophilin J
cyclophilin-like protein 3
cyclophilin-like protein PPIL3
peptidylprolyl cis-trans isomerase-like protein 3
peptidylprolyl isomerase (cyclophilin)-like 3
rotamase PPIL3
NP_115861.1
NP_570981.1
XP_005246708.1
XP_005246709.1
XP_011509660.1
XP_016859841.1
XP_016859842.1
XP_016859843.1
XP_016859844.1
XP_016859845.1
XP_054198563.1
XP_054198564.1
XP_054198565.1
XP_054198566.1
XP_054198567.1
XP_054198568.1
XP_054198569.1
XP_054198570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032472.4 → NP_115861.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3a

    See identical proteins and their annotated locations for NP_115861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PPIL3a) encodes the longer isoform (PPIL3a).
    Source sequence(s)
    AC005037, AF251049, AF271652
    Consensus CDS
    CCDS2332.1
    UniProtKB/TrEMBL
    A0A0S2Z5A8, B8ZZ77
    Related
    ENSP00000286175.8, ENST00000286175.12
    Conserved Domains (1) summary
    cl00197
    Location:1 → 158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  2. NM_130906.3 → NP_570981.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b

    See identical proteins and their annotated locations for NP_570981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PPIL3b) includes an alternate in-frame segment, compared to variant PPIL3a, resulting in a shorter protein (isoform PPIL3b), compared to isoform PPIL3a. Variants PPIL3b and PPIL3c encode the same protein.
    Source sequence(s)
    AC005037, AF271652, CB961908
    Consensus CDS
    CCDS2333.1
    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0, H7BZ14
    Related
    ENSP00000376107.4, ENST00000392283.9
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    200870907..200889291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246652.6 → XP_005246709.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    See identical proteins and their annotated locations for XP_005246709.1

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0, H7BZ14
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  2. XM_005246651.4 → XP_005246708.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_005246708.1

    UniProtKB/TrEMBL
    A0A0S2Z5A8, B8ZZ77
    Related
    ENSP00000387012.1, ENST00000409449.5
    Conserved Domains (1) summary
    cl00197
    Location:1 → 158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  3. XM_011511358.3 → XP_011509660.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    See identical proteins and their annotated locations for XP_011509660.1

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0, H7BZ14
    Related
    ENST00000465823.5
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  4. XM_017004352.2 → XP_016859841.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8, B8ZZ77
    Related
    ENSP00000386235.1, ENST00000409361.5
    Conserved Domains (1) summary
    cl00197
    Location:1 → 158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  5. XM_017004354.3 → XP_016859843.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8, B8ZZ77
    Conserved Domains (1) summary
    cl00197
    Location:1 → 158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  6. XM_017004356.3 → XP_016859845.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0, H7BZ14
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  7. XM_017004355.3 → XP_016859844.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0, H7BZ14
    Conserved Domains (1) summary
    cd01928
    Location:1 → 154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

  8. XM_017004353.2 → XP_016859842.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8, B8ZZ77
    Conserved Domains (1) summary
    cl00197
    Location:1 → 158
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201354357..201372783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342588.1 → XP_054198563.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8

  2. XM_054342592.1 → XP_054198567.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0

  3. XM_054342590.1 → XP_054198565.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8

  4. XM_054342593.1 → XP_054198568.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0

  5. XM_054342589.1 → XP_054198564.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8

  6. XM_054342595.1 → XP_054198570.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0

  7. XM_054342594.1 → XP_054198569.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8
    UniProtKB/TrEMBL
    A0A024R3V4, A0A0S2Z5G0

  8. XM_054342591.1 → XP_054198566.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5A8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131916.1: Suppressed sequence

    Description
    NM_131916.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with non-consensus splice sites in the 5' UTR.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2H8.1 GenPept UniProtKB/Swiss-Prot:Q9H2H8

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