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Ngef neuronal guanine nucleotide exchange factor [ Mus musculus (house mouse) ]

Gene ID: 53972, updated on 5-Sep-2021

Summary

Official Symbol
Ngefprovided by MGI
Official Full Name
neuronal guanine nucleotide exchange factorprovided by MGI
Primary source
MGI:MGI:1858414
See related
Ensembl:ENSMUSG00000026259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim; ephe; Tims2; ephexin
Expression
Biased expression in cortex adult (RPKM 59.5), frontal lobe adult (RPKM 38.3) and 10 other tissues See more
Orthologs
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Genomic context

See Ngef in Genome Data Viewer
Location:
1 D; 1 44.42 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87404551..87501661, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87476829..87573870, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89373404..89470445, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 13 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene predicted gene 6153 Neighboring gene predicted gene, 46099 Neighboring gene neuraminidase 2 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene predicted gene, 33470

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephexin-1
Names
eph-interacting exchange protein
transforming immortalised mammary epithelial sequence 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111314.1NP_001104784.1  ephexin-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC102564, AC157811, AI847102, AJ238898, AK138433
    Consensus CDS
    CCDS48307.1
    UniProtKB/Swiss-Prot
    Q8CHT1
    UniProtKB/TrEMBL
    E9QK62
    Related
    ENSMUSP00000066894.6, ENSMUST00000068681.12
    Conserved Domains (5) summary
    pfam02323
    Location:3156
    ELH; Egg-laying hormone precursor
    cd11939
    Location:616670
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:477603
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:490596
    PH; PH domain
    pfam00621
    Location:277456
    RhoGEF; RhoGEF domain
  2. NM_019867.2NP_063920.2  ephexin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, and lacks other coding region exons, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI847102, AJ238898, AK138433, CJ149200
    Consensus CDS
    CCDS48306.1
    UniProtKB/Swiss-Prot
    Q8CHT1
    Related
    ENSMUSP00000027477.9, ENSMUST00000027477.15
    Conserved Domains (4) summary
    cd11939
    Location:526580
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:387513
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:400506
    PH; PH domain
    pfam00621
    Location:187366
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87404551..87501661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152417.1XP_036008310.1  ephexin-1 isoform X1

    Conserved Domains (3) summary
    cd11939
    Location:339393
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:200326
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:1178
    RhoGEF; RhoGEF domain
  2. XM_036152419.1XP_036008312.1  ephexin-1 isoform X2

    Conserved Domains (1) summary
    pfam00621
    Location:277381
    RhoGEF; RhoGEF domain
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