ARPC2 actin related protein 2/3 complex subunit 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ARPC2provided by VGNC
Official Full Name: actin related protein 2/3 complex subunit 2provided by VGNC
Primary source: VGNC:VGNC:55326
See related: BGD:BT10846; Ensembl:ENSBTAG00000010386
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (106256774..106284391)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2.
Title: Analysis of the interactions between GMF and Arp2/3 complex in two binding sites by molecular dynamics simulation.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
Title: Structural basis for regulation of Arp2/3 complex by GMF.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ARPC2_(3) (e-PCR)
- UniSTS:277994

ARPC2_(5) (e-PCR)
- UniSTS:277995

D2S2896 (e-PCR)
- UniSTS:69119

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 2

Names: actin related protein 2/3 complex, subunit 2 (34 kD); actin related protein 2/3 complex, subunit 2, 34kDa; arp2/3 complex 34 kDa subunit; p34-ARC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.