Lsr lipolysis stimulated lipoprotein receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lsrprovided by MGI
Official Full Name: lipolysis stimulated lipoprotein receptorprovided by MGI
Primary source: MGI:MGI:1927471
See related: Ensembl:ENSMUSG00000001247 AllianceGenome:MGI:1927471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ILDR3; Lisch7
Summary: Predicted to enable lipoprotein particle receptor activity and low-density lipoprotein particle binding activity. Involved in several processes, including establishment of blood-brain barrier; establishment of skin barrier; and tricellular tight junction assembly. Acts upstream of or within protein localization to tricellular tight junction. Located in plasma membrane and tricellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and respiratory system. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 232.1), small intestine adult (RPKM 213.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30657195..30672894, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30957770..30973469, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LSR targets YAP to modulate intestinal Paneth cell differentiation.
Title: LSR targets YAP to modulate intestinal Paneth cell differentiation.
Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in Mice.
Title: Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in Mice.
The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts.
Title: The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts.
propose that LSR in glial cells may play a key role in glia-neuron cross talk, particularly in the feedback control of cholesterol synthesis to avoid cholesterol overload in neurons and to maintain proper functioning of the brain throughout life
Title: Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain.
Data (including data from studies using transgenic mice) suggest that plasma and liver cholesterol homeostasis and hepatic expression of LDL receptor and lipolysis-stimulated lipoprotein receptor are modulated differently and independently by APOE allele (E4 versus E3) and docosahexaenoic acid intake. (APOE = apolipoprotein E)
Title: Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice.
Findings suggest that both tricellular tight junctions proteins TRIC and LSR have crucial roles for the differentiated cochlear cell survival.
Title: Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells.
The results of this study suggest that changes in cortex cholesterol regulation as a result of the LSR+/- genotype were linked to increased susceptibility to amyloid stress.
Title: Increased susceptibility of dyslipidemic LSR+/- mice to amyloid stress is associated with changes in cortical cholesterol levels.
LSR is specifically expressed at tricellular junctions and that its expression correlates with the onset of blood-brain barrier formation during embryogenesis.
Title: LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.
The activity of JNK1 and JNK2, but not JNK3, was required for the exclusive localization of angulin-1/LSR at the tTJs.
Title: JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet.
localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo
Title: Localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498304 (e-PCR)
- UniSTS:498304

Lsr (e-PCR), detects polymorphism
- UniSTS:498304

Lsr (e-PCR), detects polymorphism
- UniSTS:498389

Lsr (e-PCR), detects polymorphism
- UniSTS:498390

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipoprotein particle receptor activity	TAS Traceable Author Statement more info	PubMed
enables low-density lipoprotein particle binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial structure maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of blood-brain barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of skin barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoprotein transport	TAS Traceable Author Statement more info	PubMed
involved_in liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to tricellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tricellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricellular tight junction assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in tricellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info
is_active_in tricellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in tricellular tight junction	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipolysis-stimulated lipoprotein receptor

Names: angulin-3; lipolysis stimulated receptor; liver-specific bHLH-Zip transcription factor; liver-specific gene on mouse chromosome 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164184.1 → NP_001157656.1 lipolysis-stimulated lipoprotein receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001157656.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC149055, AK146807, BY028179

Consensus CDS

CCDS52186.1

UniProtKB/Swiss-Prot

Q99KG5

Related

ENSMUSP00000103751.4, ENSMUST00000108116.10

Conserved Domains (2) summary

pfam08648
Location:451 → 510

DUF1777; Protein of unknown function (DUF1777)

pfam12871
Location:451 → 512

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001164185.1 → NP_001157657.1 lipolysis-stimulated lipoprotein receptor isoform 3 precursor

See identical proteins and their annotated locations for NP_001157657.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC149055, AK146807, AK167463, BY028179

Consensus CDS

CCDS52185.1

UniProtKB/Swiss-Prot

Q99KG5

Related

ENSMUSP00000096153.5, ENSMUST00000098553.11

Conserved Domains (1) summary

pfam08648
Location:402 → 461

DUF1777; Protein of unknown function (DUF1777)
NM_017405.2 → NP_059101.1 lipolysis-stimulated lipoprotein receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_059101.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC149055

Consensus CDS

CCDS21119.1

UniProtKB/Swiss-Prot

Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816, Q99KG5

Related

ENSMUSP00000001279.8, ENSMUST00000001279.15

Conserved Domains (2) summary

pfam08648
Location:470 → 529

DUF1777; Protein of unknown function (DUF1777)

pfam12871
Location:470 → 531

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term