App amyloid beta precursor protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 54226, updated on 11-Apr-2024

Summary

Official Symbol: Appprovided by RGD
Official Full Name: amyloid beta precursor proteinprovided by RGD
Primary source: RGD:2139
See related: Ensembl:ENSRNOG00000006997 AllianceGenome:RGD:2139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abeta
Summary: Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1960.2), Lung (RPKM 1647.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (37506207..37724351, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (24019774..24236584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (24425013..24641872, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of hippocampal arylalkylamine N-acetyltransferase activity in amyloid-beta neurotoxicity.
Title: Evaluation of hippocampal arylalkylamine N-acetyltransferase activity in amyloid-β neurotoxicity.
Oligomeric Abeta25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Title: Oligomeric Aβ25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Title: Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Abeta(1-42) accumulation.
Title: Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ((1-42)) accumulation.
An App knock-in rat model for Alzheimer's disease exhibiting Abeta and tau pathologies, neuronal death and cognitive impairments.
Title: An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments.
Spinal beta-amyloid1-42 acts as an endogenous analgesic peptide in CCI-induced neuropathic pain.
Title: Spinal beta-amyloid1-42 acts as an endogenous analgesic peptide in CCI-induced neuropathic pain.
A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.
Title: A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.
Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model.
Title: Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model.
Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling.
Title: Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling.
Title: Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling.

Submit: New GeneRIF Correction See all GeneRIFs (218)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:185158 (e-PCR)
- UniSTS:155414

GDB:185159 (e-PCR)
- UniSTS:155415

RH94865 (e-PCR)
- UniSTS:120111

App (e-PCR), detects polymorphism
- UniSTS:536419

App (e-PCR), detects polymorphism
- UniSTS:536420

BF389056 (e-PCR)
- UniSTS:245355

RH139209 (e-PCR)
- UniSTS:221295

APP (e-PCR)
- UniSTS:266418

BE108355 (e-PCR)
- UniSTS:247736

D11Got14 (e-PCR)
- UniSTS:113360

App (e-PCR), detects polymorphism
- UniSTS:259038

BF388494 (e-PCR)
- UniSTS:244961

BF403704 (e-PCR)
- UniSTS:246502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables PTB domain binding	IEA Inferred from Electronic Annotation more info
enables PTB domain binding	ISO Inferred from Sequence Orthology more info
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables peptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antifungal humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in axo-dendritic transport	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within axo-dendritic transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axo-dendritic transport	ISO Inferred from Sequence Orthology more info
involved_in axo-dendritic transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon midline choice point recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon midline choice point recognition	ISO Inferred from Sequence Orthology more info
involved_in axon midline choice point recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to norepinephrine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in collateral sprouting in absence of injury	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
involved_in collateral sprouting in absence of injury	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytosolic mRNA polyadenylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytosolic mRNA polyadenylation	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in low-density lipoprotein particle mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in mating behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mating behavior	ISO Inferred from Sequence Orthology more info
involved_in mating behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in microglia development	IEA Inferred from Electronic Annotation more info
involved_in microglia development	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in modulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in modulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood circulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Toll signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein trimerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of spontaneous synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synapse structure or activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structure or activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to yeast	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth endoplasmic reticulum calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in suckling behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within suckling behavior	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic assembly at neuromuscular junction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic assembly at neuromuscular junction	ISO Inferred from Sequence Orthology more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IEA Inferred from Electronic Annotation more info
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	ISS Inferred from Sequence or Structural Similarity more info
part_of amyloid-beta complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info
located_in ciliary rootlet	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
NOT located_in dendrite	ISO Inferred from Sequence Orthology more info
NOT located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome to plasma membrane transport vesicle	ISO Inferred from Sequence Orthology more info
NOT located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone lamellipodium	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in main axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
NOT located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
NOT located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amyloid-beta precursor protein

Names: ABPP; AG; alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid precursor protein; amyloidogenic glycoprotein; beta-amyloid precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019288.2 → NP_062161.1 amyloid-beta precursor protein precursor

See identical proteins and their annotated locations for NP_062161.1

Status: PROVISIONAL

Source sequence(s)

AF513015

UniProtKB/Swiss-Prot

P08592, Q547B7

UniProtKB/TrEMBL

A0A8L2QLQ8, A6JL62

Conserved Domains (5) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 341

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam03494
Location:677 → 713

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:716 → 766

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12925
Location:366 → 548

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

37506207..37724351 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248011.5 → XP_006248073.1 amyloid-beta precursor protein isoform X4

See identical proteins and their annotated locations for XP_006248073.1

UniProtKB/TrEMBL

A0A8L2QLQ8, A6JL61

Conserved Domains (6) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:600 → 638

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:641 → 691

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:291 → 473

APP_E2; E2 domain of amyloid precursor protein
XM_006248009.5 → XP_006248071.1 amyloid-beta precursor protein isoform X2

UniProtKB/TrEMBL

A0A0H2UHW9, A0A8L2QLQ8

Related

ENSRNOP00000040243.5

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:656 → 694

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:697 → 747

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:347 → 529

APP_E2; E2 domain of amyloid precursor protein
XM_006248008.5 → XP_006248070.1 amyloid-beta precursor protein isoform X1

UniProtKB/TrEMBL

A0A8I5Y8G9, A0A8L2QLQ8

Related

ENSRNOP00000078198.1

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:657 → 695

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:698 → 748

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:366 → 548

APP_E2; E2 domain of amyloid precursor protein
XM_006248012.5 → XP_006248074.1 amyloid-beta precursor protein isoform X5

UniProtKB/TrEMBL

A0A8L2QLQ8

Conserved Domains (6) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:582 → 620

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:623 → 673

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:291 → 473

APP_E2; E2 domain of amyloid precursor protein
XM_006248010.5 → XP_006248072.1 amyloid-beta precursor protein isoform X3

See identical proteins and their annotated locations for XP_006248072.1

UniProtKB/TrEMBL

A0A8L2QLQ8, Q6P6Q5

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:638 → 676

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:679 → 729

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:347 → 529

APP_E2; E2 domain of amyloid precursor protein
XM_063270722.1 → XP_063126792.1 amyloid-beta precursor protein isoform X6