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Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54246, updated on 22-Aug-2021

Summary

Official Symbol
Cyp2f4provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily f, polypeptide 4provided by RGD
Primary source
RGD:2476
See related
Ensembl:ENSRNOG00000032805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2f1; Cyp2f2; CYP4502F4
Summary
member of the p450 2F subfamily; forms styrene glycol from styrene in liver and lung microsomes [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 268.0), Liver (RPKM 139.3) and 1 other tissue See more
Orthologs
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Genomic context

See Cyp2f4 in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82416108..82429897)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83933974..83947804)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 1, pseudogene 1 Neighboring gene similar to Phosphoglycerate kinase 1 Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 1 Neighboring gene egl-9 family hypoxia-inducible factor 2 Neighboring gene RAB4B, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within naphthalene catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in naphthalene catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organic cyclic compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in trichloroethylene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome P450 2F2
Names
CYPIIF2
Cytochrome P450, subfamily IIF, polypeptide 1
P450-NAH-2
cytochrome P450, family 2, subfamily f, polypeptide 2
cytochrome P450, subfamily 2F, polypeptide 1
cytochrome P450-NAH-2
naphthalene dehydrogenase
naphthalene hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019303.2NP_062176.1  cytochrome P450 2F2 precursor

    See identical proteins and their annotated locations for NP_062176.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000033
    UniProtKB/Swiss-Prot
    O35293
    Conserved Domains (1) summary
    pfam00067
    Location:31488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    82416108..82429897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228585.3XP_006228647.1  cytochrome P450 2F2 isoform X1

    UniProtKB/Swiss-Prot
    O35293
    Related
    ENSRNOP00000058858.2
    Conserved Domains (1) summary
    pfam00067
    Location:31488
    p450; Cytochrome P450
  2. XM_039088582.1XP_038944510.1  cytochrome P450 2F2 isoform X2

    Conserved Domains (1) summary
    cl41757
    Location:1278
    cytochrome_P450; cytochrome P450 (CYP) superfamily
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