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Gp9 glycoprotein 9 platelet [ Mus musculus (house mouse) ]

Gene ID: 54368, updated on 5-Mar-2024

Summary

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Official Symbol
Gp9provided by MGI
Official Full Name
glycoprotein 9 plateletprovided by MGI
Primary source
MGI:MGI:1860137
See related
Ensembl:ENSMUSG00000030054 AllianceGenome:MGI:1860137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd42; GPIX
Summary
Predicted to act upstream of or within blood coagulation and cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; foregut; hemolymphoid system; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP9 (glycoprotein IX platelet). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 11.3), liver E14.5 (RPKM 10.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 39.13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87753115..87756768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87776131..87779786)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene EF hand and coiled-coil domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9277 Neighboring gene predicted gene, 34414 Neighboring gene 60S ribosomal protein L3 related Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of cDNA encoding full-length mouse platelet glycoprotein IX. Kitaguchi T, et al. Blood Coagul Fibrinolysis, 1998 Jun. PMID 9690810
  2. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Delaney MK, et al. Arterioscler Thromb Vasc Biol, 2012 Nov. PMID 22995516, Free PMC Article
  3. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Staron M, et al. Blood, 2011 Jun 30. PMID 21576699, Free PMC Article
  4. Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia. Nishimoto T, et al. J Thromb Haemost, 2013 Feb. PMID 23176290
  5. Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome. Strassel C, et al. Haematologica, 2009 Jun. PMID 19377075, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Platelet GP Ib-IX can be considered a multifunctional participant in hemostasis, thrombosis, and the inflammatory cascade.
    Title: Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.
  2. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia.
    Title: Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.
  3. Letter: report autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia.
    Title: Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia.
  4. A Lyn-Vav-Rac1-PI3K-Akt pathway mediates von Willebrand factor-induced activation of integrin alpha(IIb)beta(3) to promote GPIb-IX-dependent platelet activation.
    Title: The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.
  5. Data indicate that GPIX is the subunit of the glycoprotein Ib-IX-V complex that binds to grp94/Hsp90b1; the glycoprotein Ib-IX-V complex is stabilized by grp94/Hsp90b1.
    Title: Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.
  6. Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis.
    Title: Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130579

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blood coagulation, intrinsic pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation, intrinsic pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of glycoprotein Ib-IX-V complex ISO
Inferred from Sequence Orthology
more info
  
part_of glycoprotein Ib-IX-V complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet glycoprotein IX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018762.2 → NP_061232.1  platelet glycoprotein IX precursor

    See identical proteins and their annotated locations for NP_061232.1

    Status: VALIDATED

    Source sequence(s)
    AA184800, AB007464, AC158626
    Consensus CDS
    CCDS20328.1
    UniProtKB/Swiss-Prot
    O88186
    Related
    ENSMUSP00000032133.4, ENSMUST00000032133.5
    Conserved Domains (3) summary
    smart00013
    Location:19 → 53
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:46 → 76
    LRR_1; leucine-rich repeat [structural motif]
    cl15307
    Location:85 → 133
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87753115..87756768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241410.4 → XP_011239712.1  platelet glycoprotein IX isoform X1

    See identical proteins and their annotated locations for XP_011239712.1

    Conserved Domains (4) summary
    TIGR00864
    Location:77 → 143
    PCC; polycystin cation channel protein
    smart00013
    Location:38 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:65 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:75 → 105
    LRR_8; Leucine rich repeat

  2. XM_006506394.5 → XP_006506457.1  platelet glycoprotein IX isoform X1

    See identical proteins and their annotated locations for XP_006506457.1

    Conserved Domains (4) summary
    TIGR00864
    Location:77 → 143
    PCC; polycystin cation channel protein
    smart00013
    Location:38 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:65 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:75 → 105
    LRR_8; Leucine rich repeat

  3. XM_017321682.3 → XP_017177171.1  platelet glycoprotein IX isoform X1

    Conserved Domains (4) summary
    TIGR00864
    Location:77 → 143
    PCC; polycystin cation channel protein
    smart00013
    Location:38 → 72
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:65 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:75 → 105
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88186.1 GenPept UniProtKB/Swiss-Prot:O88186

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