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Mtmr7 myotubularin related protein 7 [ Mus musculus (house mouse) ]

Gene ID: 54384, updated on 23-Jun-2021

Summary

Official Symbol
Mtmr7provided by MGI
Official Full Name
myotubularin related protein 7provided by MGI
Primary source
MGI:MGI:1891693
See related
Ensembl:ENSMUSG00000039431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 9.0) and 21 other tissues See more
Orthologs
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Genomic context

See Mtmr7 in Genome Data Viewer
Location:
8; 8 A4
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41003184..41088210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40548199..40634935, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (41635513..41720146, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene a disintegrin and metallopeptidase domain 24 (testase 1) Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol bisphosphate phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myotubularin-related protein 7
Names
inositol 1,3-bisphosphate phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_001035789.1
XP_006509530.1
XP_006509532.1
XP_017168391.1
XP_036010070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040699.1NP_001035789.1  myotubularin-related protein 7

    See identical proteins and their annotated locations for NP_001035789.1

    Status: VALIDATED

    Source sequence(s)
    AC158915, AK081973, BY741806
    Consensus CDS
    CCDS40324.1
    UniProtKB/Swiss-Prot
    Q9Z2C9
    Related
    ENSMUSP00000043851.11, ENSMUST00000048898.17
    Conserved Domains (2) summary
    cd13344
    Location:1103
    PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:109446
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41003184..41088210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154177.1XP_036010070.1  myotubularin-related protein 7 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:1212
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_017312902.3XP_017168391.1  myotubularin-related protein 7 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:1295
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_006509467.5XP_006509530.1  myotubularin-related protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006509530.1

    Conserved Domains (1) summary
    cl28904
    Location:1212
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_006509469.5XP_006509532.1  myotubularin-related protein 7 isoform X3

    Conserved Domains (1) summary
    pfam06602
    Location:1151
    Myotub-related; Myotubularin-like phosphatase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019433.1: Suppressed sequence

    Description
    NM_019433.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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