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Ppt2 palmitoyl-protein thioesterase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54398, updated on 5-Mar-2024

Summary

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Official Symbol
Ppt2provided by RGD
Official Full Name
palmitoyl-protein thioesterase 2provided by RGD
Primary source
RGD:620375
See related
Ensembl:ENSRNOG00000000435 AllianceGenome:RGD:620375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable palmitoyl hydrolase activity and thiolester hydrolase activity. Predicted to be involved in macromolecule depalmitoylation. Predicted to be active in lysosome. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 61.8), Kidney (RPKM 54.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4117088..4137382)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4112520..4132774)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4381455..4401638, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta Neighboring gene FKBP prolyl isomerase like Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene ring finger protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features. Gupta P, et al. Proc Natl Acad Sci U S A, 2003 Oct 14. PMID 14528005, Free PMC Article
  2. Characterization of a human MHC class III region gene product with S-thioesterase activity. Aguado B, et al. Biochem J, 1999 Aug 1. PMID 10417332, Free PMC Article
  3. Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. Soyombo AA, et al. J Biol Chem, 1997 Oct 24. PMID 9341199
  4. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717424, Free PMC Article
  5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiolester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysosomal thioesterase PPT2
NP_062240.1
XP_006256079.2
XP_006256081.1
XP_006256082.1
XP_006256084.1
XP_006256085.1
XP_008770984.1
XP_038954969.1
XP_038954973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019367.2 → NP_062240.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_062240.1

    Status: VALIDATED

    Source sequence(s)
    BC062023, CB736242
    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Related
    ENSRNOP00000000497.5, ENSRNOT00000000497.8
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4117088..4137382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256017.4 → XP_006256079.2  lysosomal thioesterase PPT2 isoform X1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  2. XM_039099041.2 → XP_038954969.1  lysosomal thioesterase PPT2 isoform X2

    Conserved Domains (1) summary
    pfam02089
    Location:62 → 205
    Palm_thioest; Palmitoyl protein thioesterase

  3. XM_006256023.4 → XP_006256085.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_006256085.1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  4. XM_006256020.5 → XP_006256082.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_006256082.1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  5. XM_006256022.5 → XP_006256084.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_006256084.1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Related
    ENSRNOP00000074361.2
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  6. XM_006256019.4 → XP_006256081.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_006256081.1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  7. XM_008772762.4 → XP_008770984.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_008770984.1

    UniProtKB/Swiss-Prot
    O70489, O88500
    UniProtKB/TrEMBL
    A0A8L2R8R8, A6KTI0
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 283
    Palm_thioest; Palmitoyl protein thioesterase

  8. XM_039099045.2 → XP_038954973.1  lysosomal thioesterase PPT2 isoform X3

    Conserved Domains (1) summary
    pfam02089
    Location:27 → 182
    Palm_thioest; Palmitoyl protein thioesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70489.1 GenPept UniProtKB/Swiss-Prot:O70489

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