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Myh13 myosin, heavy polypeptide 13, skeletal muscle [ Mus musculus (house mouse) ]

Gene ID: 544791, updated on 5-Mar-2024

Summary

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Official Symbol
Myh13provided by MGI
Official Full Name
myosin, heavy polypeptide 13, skeletal muscleprovided by MGI
Primary source
MGI:MGI:1339967
See related
Ensembl:ENSMUSG00000060180 AllianceGenome:MGI:1339967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MyHC-eo
Summary
Acts upstream of or within cellular response to starvation. Located in myofibril. Orthologous to human MYH13 (myosin heavy chain 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 3.6), limb E14.5 (RPKM 1.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 40.85 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67217929..67262413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67327103..67371587)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG) Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene STARR-seq mESC enhancer starr_29799 Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459 Neighboring gene STARR-seq mESC enhancer starr_29801 Neighboring gene growth arrest specific 7 Neighboring gene STARR-positive B cell enhancer ABC_E10680 Neighboring gene predicted gene 12301

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. Winters LM, et al. Genomics, 1998 Nov 15. PMID 9806854
  2. A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes. Dos Santos M, et al. Nat Commun, 2022 Feb 24. PMID 35210422, Free PMC Article
  3. Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. Lagirand-Cantaloube J, et al. PLoS One, 2009. PMID 19319192, Free PMC Article
  4. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. Weiss A, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077619, Free PMC Article
  5. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Sambasivan R, et al. Dev Cell, 2009 Jun. PMID 19531352

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles.
    Title: MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-13
Names
EO Myosin
extraocular myosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081250.2 → NP_001074719.1  myosin-13

    Status: VALIDATED

    Source sequence(s)
    AL596255, BX255958
    Consensus CDS
    CCDS36185.1
    UniProtKB/TrEMBL
    B1AR69
    Related
    ENSMUSP00000080584.6, ENSMUST00000081911.12
    Conserved Domains (6) summary
    cd14923
    Location:100 → 770
    MYSc_Myh13; class II myosin heavy chain 13, motor domain
    pfam00063
    Location:88 → 770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:850 → 1927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1744 → 1837
    TMPIT; TMPIT-like protein
    cl19219
    Location:1506 → 1582
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67217929..67262413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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