Format

Send to:

Choose Destination

Kalrn kalirin, RhoGEF kinase [ Mus musculus (house mouse) ]

Gene ID: 545156, updated on 23-Jun-2021

Summary

Official Symbol
Kalrnprovided by MGI
Official Full Name
kalirin, RhoGEF kinaseprovided by MGI
Primary source
MGI:MGI:2685385
See related
Ensembl:ENSMUSG00000061751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H; DUET; TRAD; Gm539; Hapip; AV235988; 2210407G14Rik; E530005C20Rik
Expression
Biased expression in cortex adult (RPKM 11.3), frontal lobe adult (RPKM 7.9) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kalrn in Genome Data Viewer
Location:
16; 16 B3
Exon count:
69
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33789443..34393647, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33969073..34573277, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (33969159..34514113, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene integrin beta 5 Neighboring gene VISTA enhancer mm268 Neighboring gene uridine monophosphate synthetase Neighboring gene predicted gene, 41448 Neighboring gene ropporin, rhophilin associated protein 1 Neighboring gene predicted gene, 35150 Neighboring gene coiled-coil domain containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to formalin induced pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal process involved in parturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kalirin
Names
huntingtin-associated protein interacting protein (duo)
protein Duo
serine/threonine kinase with Dbl- and pleckstrin homology domain
serine/threonine kinase with Dbl- and pleckstrin homology domains
serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
NP_001157740.1
NP_796331.2
XP_006522426.1
XP_006522427.1
XP_006522433.1
XP_006522443.1
XP_006522444.1
XP_006522445.1
XP_006522446.1
XP_006522448.1
XP_006522449.1
XP_011244253.1
XP_011244254.1
XP_011244255.1
XP_011244256.1
XP_011244257.1
XP_011244258.1
XP_011244259.1
XP_011244260.1
XP_011244261.1
XP_011244262.1
XP_011244263.1
XP_011244265.1
XP_011244267.1
XP_011244268.1
XP_011244269.1
XP_011244270.1
XP_017172560.1
XP_017172561.1
XP_017172562.1
XP_017172563.1
XP_017172564.1
XP_017172565.1
XP_017172566.1
XP_017172568.1
XP_017172569.1
XP_017172570.1
XP_017172571.1
XP_030105050.1
XP_030105051.1
XP_030105052.1
XP_036015907.1
XP_036015909.1
XP_036015910.1
XP_036015912.1
XP_036015913.1
XP_036015914.1
XP_036015916.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164268.1NP_001157740.1  kalirin isoform 2

    See identical proteins and their annotated locations for NP_001157740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147518, BC157950
    Consensus CDS
    CCDS49836.1
    UniProtKB/Swiss-Prot
    A2CG49
    Related
    ENSMUSP00000110611.3, ENSMUST00000114960.9
    Conserved Domains (5) summary
    smart00150
    Location:11261226
    SPEC; Spectrin repeats
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12751445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14521574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
  2. NM_177357.3NP_796331.2  kalirin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AC154524, AC154588, AC165079, CT010573
    Related
    ENSMUSP00000076088.6, ENSMUST00000076810.12
    Conserved Domains (17) summary
    cd00096
    Location:24782552
    Ig; Immunoglobulin domain
    smart00150
    Location:11261226
    SPEC; Spectrin repeats
    cd11852
    Location:16401699
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23142370
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:26742928
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25592650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12751445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22422294
    Extensin_2; Extensin-like region
    pfam07679
    Location:24612555
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14521574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20962230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26802927
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:14851570
    PH; PH domain
    pfam00621
    Location:19222092
    RhoGEF; RhoGEF domain
    pfam16609
    Location:16971921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33789443..34393647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245955.2XP_011244257.1  kalirin isoform X6

    Conserved Domains (14) summary
    smart00150
    Location:11371237
    SPEC; Spectrin repeats
    cd11852
    Location:16511710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23252381
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25702661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12861456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8931131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22532305
    Extensin_2; Extensin-like region
    cd13240
    Location:14631585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21072241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26912938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19332102
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24722566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17081923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  2. XM_006522386.4XP_006522449.1  kalirin isoform X45

    Conserved Domains (14) summary
    smart00150
    Location:11211221
    SPEC; Spectrin repeats
    cd11852
    Location:16351694
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23092365
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25342625
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12701440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8861115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22372289
    Extensin_2; Extensin-like region
    cd13240
    Location:14471569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20912225
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26552902
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19172086
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24362530
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16921907
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  3. XM_006522370.4XP_006522433.1  kalirin isoform X11

    Conserved Domains (14) summary
    smart00150
    Location:11211221
    SPEC; Spectrin repeats
    cd11852
    Location:16351694
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23092365
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25542645
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12701440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8861115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22372289
    Extensin_2; Extensin-like region
    cd13240
    Location:14471569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20912225
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26752922
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19172086
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24562550
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16921907
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  4. XM_036160016.1XP_036015909.1  kalirin isoform X16

    Conserved Domains (14) summary
    smart00150
    Location:11301230
    SPEC; Spectrin repeats
    cd11852
    Location:16441703
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22862342
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25312622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12791449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14561578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20692203
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26522899
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:18952064
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24332527
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17011892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:24252428
    Ig; Ig strand A [structural motif]
  5. XM_011245956.3XP_011244258.1  kalirin isoform X9

    Conserved Domains (14) summary
    smart00150
    Location:11301230
    SPEC; Spectrin repeats
    cd11852
    Location:16441703
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23182374
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25632654
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12791449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22462298
    Extensin_2; Extensin-like region
    cd13240
    Location:14561578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21002234
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26842931
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19262095
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24652559
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17011916
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  6. XM_006522364.4XP_006522427.1  kalirin isoform X8

    Conserved Domains (14) summary
    smart00150
    Location:11341234
    SPEC; Spectrin repeats
    cd11852
    Location:16481707
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23222378
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25672658
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12831453
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991128
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22502302
    Extensin_2; Extensin-like region
    cd13240
    Location:14601582
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21042238
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26882935
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19302099
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24692563
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17051920
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  7. XM_011245961.3XP_011244263.1  kalirin isoform X14

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22992355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25442635
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22272279
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20812215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26652912
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19072076
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24462540
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  8. XM_036160014.1XP_036015907.1  kalirin isoform X4

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23292385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25742665
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21122246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26952942
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19382107
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24762570
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141895
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:24682471
    Ig; Ig strand A [structural motif]
  9. XM_011245952.3XP_011244254.1  kalirin isoform X2

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25752666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22582310
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21122246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26962943
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19382107
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24772571
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  10. XM_017317071.2XP_017172560.1  kalirin isoform X15

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22992355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25442635
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22282280
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20822216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26652912
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19082077
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24462540
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  11. XM_011245960.3XP_011244262.1  kalirin isoform X13

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23002356
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25452636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22282280
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20822216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26662913
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19082077
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24472541
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  12. XM_011245953.3XP_011244255.1  kalirin isoform X3

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25752666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26962943
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24772571
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  13. XM_011245957.3XP_011244259.1  kalirin isoform X10

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25562647
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26772924
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24582552
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  14. XM_011245951.3XP_011244253.1  kalirin isoform X1

    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25762667
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26972944
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24782572
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  15. XM_006522363.5XP_006522426.1  kalirin isoform X7

    Conserved Domains (14) summary
    smart00150
    Location:11351235
    SPEC; Spectrin repeats
    cd11852
    Location:16491708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23232379
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25682659
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12841454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22512303
    Extensin_2; Extensin-like region
    cd13240
    Location:14611583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21052239
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26892936
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19312100
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24702564
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17061921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  16. XM_011245954.4XP_011244256.1  kalirin isoform X5

    Conserved Domains (14) summary
    smart00150
    Location:11381238
    SPEC; Spectrin repeats
    cd11852
    Location:16521711
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23262382
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:42180
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25712662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12871457
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8941132
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22542306
    Extensin_2; Extensin-like region
    cd13240
    Location:14641586
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21082242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26922939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19342103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24732567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17091924
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  17. XM_011245959.3XP_011244261.1  kalirin isoform X12

    See identical proteins and their annotated locations for XP_011244261.1

    Conserved Domains (14) summary
    smart00150
    Location:11171217
    SPEC; Spectrin repeats
    cd11852
    Location:16311690
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23052361
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:21159
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25502641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12661436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8731111
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22332285
    Extensin_2; Extensin-like region
    cd13240
    Location:14431565
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20872221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26712918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19132082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24522546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16881903
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  18. XM_011245958.3XP_011244260.1  kalirin isoform X12

    See identical proteins and their annotated locations for XP_011244260.1

    Conserved Domains (14) summary
    smart00150
    Location:11171217
    SPEC; Spectrin repeats
    cd11852
    Location:16311690
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23052361
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:21159
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:25502641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:12661436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8731111
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22332285
    Extensin_2; Extensin-like region
    cd13240
    Location:14431565
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20872221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:26712918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:19132082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:24522546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16881903
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  19. XM_006522381.1XP_006522444.1  kalirin isoform X33

    Conserved Domains (13) summary
    smart00150
    Location:481581
    SPEC; Spectrin repeats
    cd11852
    Location:9951054
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:16691725
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:19142005
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:630800
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:237475
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:15971649
    Extensin_2; Extensin-like region
    cd13240
    Location:807929
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:14511585
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:20352282
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:12771446
    RhoGEF; RhoGEF domain
    pfam07679
    Location:18161910
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:10521267
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  20. XM_036160023.1XP_036015916.1  kalirin isoform X32

    Conserved Domains (13) summary
    smart00150
    Location:485585
    SPEC; Spectrin repeats
    cd11852
    Location:9991058
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:16731729
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:19182009
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:634804
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:250479
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:811933
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:14551589
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:20392286
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:12811450
    RhoGEF; RhoGEF domain
    pfam07679
    Location:18201914
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:10561238
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:18121815
    Ig; Ig strand A [structural motif]
  21. XM_006522380.1XP_006522443.1  kalirin isoform X31

    Conserved Domains (14) summary
    smart00150
    Location:494594
    SPEC; Spectrin repeats
    cd11852
    Location:10081067
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:16821738
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:19272018
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:643813
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:250488
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:16101662
    Extensin_2; Extensin-like region
    cd13240
    Location:820942
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:14641598
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:20482295
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cl02488
    Location:5249
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00621
    Location:12901459
    RhoGEF; RhoGEF domain
    pfam07679
    Location:18291923
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:10651280
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  22. XM_006522385.5XP_006522448.1  kalirin isoform X39

    UniProtKB/TrEMBL
    D3Z4R2
    Related
    ENSMUSP00000110624.2, ENSMUST00000114973.9
    Conserved Domains (7) summary
    cd11853
    Location:627683
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:872963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:409543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:9931240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:235404
    RhoGEF; RhoGEF domain
    pfam07679
    Location:774868
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:23225
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  23. XM_017317077.3XP_017172566.1  kalirin isoform X40

    Conserved Domains (7) summary
    cd11853
    Location:626682
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:871962
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:409543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:9921239
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:235404
    RhoGEF; RhoGEF domain
    pfam07679
    Location:773867
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:23225
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  24. XM_036160017.1XP_036015910.1  kalirin isoform X18

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141896
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  25. XM_036160019.1XP_036015912.1  kalirin isoform X19

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141896
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  26. XM_011245963.3XP_011244265.1  kalirin isoform X17

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  27. XM_030249191.1XP_030105051.1  kalirin isoform X28

    Conserved Domains (12) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22992355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22272279
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20812215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19072076
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  28. XM_036160020.1XP_036015913.1  kalirin isoform X23

    Conserved Domains (10) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21122246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19382107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141895
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  29. XM_036160021.1XP_036015914.1  kalirin isoform X27

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23002356
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20822216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19082077
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141905
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  30. XM_011245965.3XP_011244267.1  kalirin isoform X20

    Related
    ENSMUSP00000116188.2, ENSMUST00000142817.8
    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  31. XM_011245966.3XP_011244268.1  kalirin isoform X21

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23312387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  32. XM_017317074.2XP_017172563.1  kalirin isoform X30

    Conserved Domains (12) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22982354
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22272279
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20812215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19072076
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  33. XM_030249190.1XP_030105050.1  kalirin isoform X25

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23292385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22582310
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21122246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19382107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  34. XM_030249192.1XP_030105052.1  kalirin isoform X29

    Conserved Domains (12) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:22992355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22282280
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20822216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19082077
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  35. XM_017317072.3XP_017172561.1  kalirin isoform X22

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  36. XM_011245967.3XP_011244269.1  kalirin isoform X24

    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23302386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22592311
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21132247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:19392108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  37. XM_017317073.2XP_017172562.1  kalirin isoform X26

    Conserved Domains (12) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16571716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:23292385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:22582310
    Extensin_2; Extensin-like region
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21122246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:19382107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:17141928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  38. XM_017317082.3XP_017172571.1  kalirin isoform X44

    Conserved Domains (5) summary
    cd11853
    Location:594650
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:523575
    Extensin_2; Extensin-like region
    cd13241
    Location:377511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23158
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  39. XM_017317080.3XP_017172569.1  kalirin isoform X42

    Conserved Domains (5) summary
    cd11853
    Location:595651
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:523575
    Extensin_2; Extensin-like region
    cd13241
    Location:377511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23158
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  40. XM_017317081.3XP_017172570.1  kalirin isoform X43

    Conserved Domains (5) summary
    cd11853
    Location:595651
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:524576
    Extensin_2; Extensin-like region
    cd13241
    Location:378512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23159
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  41. XM_017317079.3XP_017172568.1  kalirin isoform X41

    Related
    ENSMUSP00000110615.2, ENSMUST00000114964.8
    Conserved Domains (5) summary
    cd11853
    Location:596652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:524576
    Extensin_2; Extensin-like region
    cd13241
    Location:378512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23159
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  42. XM_017317076.3XP_017172565.1  kalirin isoform X38

    Conserved Domains (5) summary
    smart00150
    Location:11211221
    SPEC; Spectrin repeats
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12701440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8861115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14471569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
  43. XM_017317075.3XP_017172564.1  kalirin isoform X37

    Conserved Domains (5) summary
    smart00150
    Location:11301230
    SPEC; Spectrin repeats
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12791449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14561578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
  44. XM_006522383.5XP_006522446.1  kalirin isoform X36

    Conserved Domains (5) summary
    smart00150
    Location:11341234
    SPEC; Spectrin repeats
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12831453
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991128
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14601582
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
  45. XM_011245968.4XP_011244270.1  kalirin isoform X34

    Conserved Domains (6) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    smart00516
    Location:47185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12921462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8991137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14691591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    TIGR02168
    Location:753999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  46. XM_006522382.5XP_006522445.1  kalirin isoform X35

    UniProtKB/Swiss-Prot
    A2CG49
    Related
    ENSMUSP00000087084.6, ENSMUST00000089655.12
    Conserved Domains (5) summary
    smart00150
    Location:11351235
    SPEC; Spectrin repeats
    smart00516
    Location:39177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12841454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:8911129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14611583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

RNA

  1. XR_001781845.2 RNA Sequence

  2. XR_001781844.2 RNA Sequence

Support Center