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Kalrn kalirin, RhoGEF kinase [ Mus musculus (house mouse) ]

Gene ID: 545156, updated on 21-Apr-2024

Summary

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Official Symbol
Kalrnprovided by MGI
Official Full Name
kalirin, RhoGEF kinaseprovided by MGI
Primary source
MGI:MGI:2685385
See related
Ensembl:ENSMUSG00000061751 AllianceGenome:MGI:2685385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUET; TRAD; Gm539; Hapip; 2210407G14Rik; E530005C20Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in postsynaptic density. Is expressed in dorsal root ganglion and spinal cord. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 11.3), frontal lobe adult (RPKM 7.9) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 24.27 cM
Exon count:
69
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33789443..34393647, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33969073..34573277, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene STARR-seq mESC enhancer starr_40719 Neighboring gene integrin beta 5 Neighboring gene STARR-positive B cell enhancer ABC_E8630 Neighboring gene STARR-seq mESC enhancer starr_40721 Neighboring gene VISTA enhancer mm268 Neighboring gene uridine monophosphate synthetase Neighboring gene STARR-seq mESC enhancer starr_40723 Neighboring gene STARR-seq mESC enhancer starr_40724 Neighboring gene predicted gene, 41448 Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene STARR-positive B cell enhancer ABC_E5539 Neighboring gene ropporin, rhophilin associated protein 1 Neighboring gene predicted gene, 35150 Neighboring gene coiled-coil domain containing 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development. Grubisha MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 7. PMID 34848542, Free PMC Article
  2. Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function. Zaccard CR, et al. Neuron, 2020 Aug 5. PMID 32464088, Free PMC Article
  3. Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice. Krivinko JM, et al. Neurobiol Aging, 2017 Jun. PMID 28319837, Free PMC Article
  4. Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice. Moyer CE, et al. Cereb Cortex, 2016 May. PMID 25759333, Free PMC Article
  5. Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl. Ma XM, et al. Mol Biol Cell, 2014 May. PMID 24600045, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
    Title: Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
  2. KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
    Title: KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
  3. Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
    Title: Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
  4. Kalirin reduction in APPswe/PSEN1dE9 mice significantly attenuated psychosis-associated behavior at 12 months of age without changing spatial memory performance.
    Title: Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
  5. Kalirin-7 plays a prominent role in nociceptive sensitization via activity-dependent modulation of spinal synapses.
    Title: A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
  6. lack of Kalrn expression in POMC cells closely mimicked the effects of global Kalrn knockout on anxiety-like behavior and passive avoidance conditioning
    Title: Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
  7. Kal7 may allow coordination of the many signaling pathways contributing to dendritic spine morphogenesis.
    Title: Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.
  8. Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass.
    Title: The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
  9. Kalerin-7 knock-out mice exhibit increased self-administration of cocaine compared to wild-type mice.
    Title: Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.
  10. Many of the widespread and diverse deficits observed both within and outside of the nervous system when expression of Kalrn is eliminated may reflect its role in secretory granule function and its expression outside of the nervous system.
    Title: Kalrn plays key roles within and outside of the nervous system.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maternal process involved in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kalirin
Names
huntingtin-associated protein interacting protein (duo)
protein Duo
serine/threonine kinase with Dbl- and pleckstrin homology domain
serine/threonine kinase with Dbl- and pleckstrin homology domains
serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
NP_001157740.1
NP_796331.2
XP_006522426.1
XP_006522427.1
XP_006522433.1
XP_006522443.1
XP_006522444.1
XP_006522445.1
XP_006522446.1
XP_006522448.1
XP_006522449.1
XP_011244253.1
XP_011244254.1
XP_011244255.1
XP_011244256.1
XP_011244257.1
XP_011244258.1
XP_011244259.1
XP_011244260.1
XP_011244261.1
XP_011244262.1
XP_011244263.1
XP_011244265.1
XP_011244267.1
XP_011244268.1
XP_011244269.1
XP_011244270.1
XP_017172560.1
XP_017172561.1
XP_017172562.1
XP_017172563.1
XP_017172564.1
XP_017172565.1
XP_017172566.1
XP_017172568.1
XP_017172569.1
XP_017172570.1
XP_017172571.1
XP_030105050.1
XP_030105051.1
XP_030105052.1
XP_036015907.1
XP_036015909.1
XP_036015910.1
XP_036015912.1
XP_036015913.1
XP_036015914.1
XP_036015916.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164268.1 → NP_001157740.1  kalirin isoform 2

    See identical proteins and their annotated locations for NP_001157740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147518, BC157950
    Consensus CDS
    CCDS49836.1
    UniProtKB/TrEMBL
    B1B1A7
    Related
    ENSMUSP00000110611.3, ENSMUST00000114960.9
    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  2. NM_177357.3 → NP_796331.2  kalirin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AC154524, AC154588, AC165079, CT010573
    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Related
    ENSMUSP00000076088.6, ENSMUST00000076810.12
    Conserved Domains (17) summary
    cd00096
    Location:2478 → 2552
    Ig; Immunoglobulin domain
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    cd11852
    Location:1640 → 1699
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2314 → 2370
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2674 → 2928
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2559 → 2650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2242 → 2294
    Extensin_2; Extensin-like region
    pfam07679
    Location:2461 → 2555
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2096 → 2230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2680 → 2927
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1485 → 1570
    PH; PH domain
    pfam00621
    Location:1922 → 2092
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1697 → 1921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33789443..34393647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245955.2 → XP_011244257.1  kalirin isoform X6

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2381
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2253 → 2305
    Extensin_2; Extensin-like region
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2107 → 2241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1933 → 2102
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  2. XM_006522386.4 → XP_006522449.1  kalirin isoform X45

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1121 → 1221
    SPEC; Spectrin repeats
    cd11852
    Location:1635 → 1694
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2309 → 2365
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2534 → 2625
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1270 → 1440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:886 → 1115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2237 → 2289
    Extensin_2; Extensin-like region
    cd13240
    Location:1447 → 1569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2091 → 2225
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2655 → 2902
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1917 → 2086
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2436 → 2530
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1692 → 1907
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  3. XM_006522370.4 → XP_006522433.1  kalirin isoform X11

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1121 → 1221
    SPEC; Spectrin repeats
    cd11852
    Location:1635 → 1694
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2309 → 2365
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2554 → 2645
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1270 → 1440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:886 → 1115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2237 → 2289
    Extensin_2; Extensin-like region
    cd13240
    Location:1447 → 1569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2091 → 2225
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2675 → 2922
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1917 → 2086
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2456 → 2550
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1692 → 1907
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  4. XM_036160016.1 → XP_036015909.1  kalirin isoform X16

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1130 → 1230
    SPEC; Spectrin repeats
    cd11852
    Location:1644 → 1703
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2286 → 2342
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2531 → 2622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1279 → 1449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545 → 761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1456 → 1578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2069 → 2203
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2652 → 2899
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1895 → 2064
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2433 → 2527
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1701 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2425 → 2428
    Ig; Ig strand A [structural motif]

  5. XM_011245956.3 → XP_011244258.1  kalirin isoform X9

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1130 → 1230
    SPEC; Spectrin repeats
    cd11852
    Location:1644 → 1703
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2318 → 2374
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2563 → 2654
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1279 → 1449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545 → 761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2246 → 2298
    Extensin_2; Extensin-like region
    cd13240
    Location:1456 → 1578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2100 → 2234
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2684 → 2931
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1926 → 2095
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2465 → 2559
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1701 → 1916
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  6. XM_006522364.4 → XP_006522427.1  kalirin isoform X8

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1134 → 1234
    SPEC; Spectrin repeats
    cd11852
    Location:1648 → 1707
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2322 → 2378
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2567 → 2658
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1283 → 1453
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1128
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2250 → 2302
    Extensin_2; Extensin-like region
    cd13240
    Location:1460 → 1582
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2104 → 2238
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2688 → 2935
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1930 → 2099
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2469 → 2563
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1705 → 1920
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  7. XM_011245961.3 → XP_011244263.1  kalirin isoform X14

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2299 → 2355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2544 → 2635
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2227 → 2279
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2081 → 2215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2665 → 2912
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1907 → 2076
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2446 → 2540
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  8. XM_036160014.1 → XP_036015907.1  kalirin isoform X4

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2329 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2574 → 2665
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2112 → 2246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2695 → 2942
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1938 → 2107
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2476 → 2570
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1895
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2468 → 2471
    Ig; Ig strand A [structural motif]

  9. XM_011245952.3 → XP_011244254.1  kalirin isoform X2

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2575 → 2666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2258 → 2310
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2112 → 2246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2696 → 2943
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1938 → 2107
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2477 → 2571
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_017317071.2 → XP_017172560.1  kalirin isoform X15

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2299 → 2355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2544 → 2635
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2228 → 2280
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2082 → 2216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2665 → 2912
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1908 → 2077
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2446 → 2540
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  11. XM_011245960.3 → XP_011244262.1  kalirin isoform X13

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2300 → 2356
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2545 → 2636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2228 → 2280
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2082 → 2216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2666 → 2913
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1908 → 2077
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2447 → 2541
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  12. XM_011245953.3 → XP_011244255.1  kalirin isoform X3

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2575 → 2666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2696 → 2943
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2477 → 2571
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  13. XM_011245957.3 → XP_011244259.1  kalirin isoform X10

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2556 → 2647
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2677 → 2924
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2458 → 2552
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  14. XM_011245951.3 → XP_011244253.1  kalirin isoform X1

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2576 → 2667
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2697 → 2944
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2478 → 2572
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  15. XM_006522363.5 → XP_006522426.1  kalirin isoform X7

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2323 → 2379
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2568 → 2659
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2251 → 2303
    Extensin_2; Extensin-like region
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2105 → 2239
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2689 → 2936
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1931 → 2100
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2470 → 2564
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1706 → 1921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  16. XM_011245954.4 → XP_011244256.1  kalirin isoform X5

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1138 → 1238
    SPEC; Spectrin repeats
    cd11852
    Location:1652 → 1711
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2382
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:42 → 180
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1287 → 1457
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:894 → 1132
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2254 → 2306
    Extensin_2; Extensin-like region
    cd13240
    Location:1464 → 1586
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1709 → 1924
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  17. XM_011245959.3 → XP_011244261.1  kalirin isoform X12

    See identical proteins and their annotated locations for XP_011244261.1

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1117 → 1217
    SPEC; Spectrin repeats
    cd11852
    Location:1631 → 1690
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2361
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:21 → 159
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2550 → 2641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1266 → 1436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:873 → 1111
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2233 → 2285
    Extensin_2; Extensin-like region
    cd13240
    Location:1443 → 1565
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2671 → 2918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1913 → 2082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2452 → 2546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1688 → 1903
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  18. XM_011245958.3 → XP_011244260.1  kalirin isoform X12

    See identical proteins and their annotated locations for XP_011244260.1

    UniProtKB/Swiss-Prot
    A2CG49, A2CG50, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Conserved Domains (14) summary
    smart00150
    Location:1117 → 1217
    SPEC; Spectrin repeats
    cd11852
    Location:1631 → 1690
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2361
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:21 → 159
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2550 → 2641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1266 → 1436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:873 → 1111
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2233 → 2285
    Extensin_2; Extensin-like region
    cd13240
    Location:1443 → 1565
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2671 → 2918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1913 → 2082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2452 → 2546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1688 → 1903
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  19. XM_006522381.1 → XP_006522444.1  kalirin isoform X33

    Conserved Domains (13) summary
    smart00150
    Location:481 → 581
    SPEC; Spectrin repeats
    cd11852
    Location:995 → 1054
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:1669 → 1725
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:1914 → 2005
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:630 → 800
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:237 → 475
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:1597 → 1649
    Extensin_2; Extensin-like region
    cd13240
    Location:807 → 929
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1451 → 1585
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2035 → 2282
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1277 → 1446
    RhoGEF; RhoGEF domain
    pfam07679
    Location:1816 → 1910
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1052 → 1267
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  20. XM_036160023.1 → XP_036015916.1  kalirin isoform X32

    Conserved Domains (13) summary
    smart00150
    Location:485 → 585
    SPEC; Spectrin repeats
    cd11852
    Location:999 → 1058
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:1673 → 1729
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:1918 → 2009
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:634 → 804
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:250 → 479
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:811 → 933
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1455 → 1589
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2039 → 2286
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1281 → 1450
    RhoGEF; RhoGEF domain
    pfam07679
    Location:1820 → 1914
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1056 → 1238
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:1812 → 1815
    Ig; Ig strand A [structural motif]

  21. XM_006522380.1 → XP_006522443.1  kalirin isoform X31

    Conserved Domains (14) summary
    smart00150
    Location:494 → 594
    SPEC; Spectrin repeats
    cd11852
    Location:1008 → 1067
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:1682 → 1738
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:1927 → 2018
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:643 → 813
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:250 → 488
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:1610 → 1662
    Extensin_2; Extensin-like region
    cd13240
    Location:820 → 942
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1464 → 1598
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2048 → 2295
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cl02488
    Location:5 → 249
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00621
    Location:1290 → 1459
    RhoGEF; RhoGEF domain
    pfam07679
    Location:1829 → 1923
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1065 → 1280
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  22. XM_006522385.5 → XP_006522448.1  kalirin isoform X39

    UniProtKB/TrEMBL
    D3Z4R2
    Related
    ENSMUSP00000110624.2, ENSMUST00000114973.9
    Conserved Domains (7) summary
    cd11853
    Location:627 → 683
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:872 → 963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:993 → 1240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam07679
    Location:774 → 868
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:23 → 225
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  23. XM_017317077.3 → XP_017172566.1  kalirin isoform X40

    Conserved Domains (7) summary
    cd11853
    Location:626 → 682
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:871 → 962
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:992 → 1239
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam07679
    Location:773 → 867
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:23 → 225
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  24. XM_036160017.1 → XP_036015910.1  kalirin isoform X18

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1896
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  25. XM_036160019.1 → XP_036015912.1  kalirin isoform X19

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1896
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  26. XM_011245963.3 → XP_011244265.1  kalirin isoform X17

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  27. XM_030249191.1 → XP_030105051.1  kalirin isoform X28

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (12) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2299 → 2355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2227 → 2279
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2081 → 2215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1907 → 2076
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  28. XM_036160020.1 → XP_036015913.1  kalirin isoform X23

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (10) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2112 → 2246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1938 → 2107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1895
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  29. XM_036160021.1 → XP_036015914.1  kalirin isoform X27

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2300 → 2356
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2082 → 2216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1908 → 2077
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1905
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  30. XM_011245965.3 → XP_011244267.1  kalirin isoform X20

    UniProtKB/TrEMBL
    F6QYT9
    Related
    ENSMUSP00000116188.2, ENSMUST00000142817.8
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  31. XM_011245966.3 → XP_011244268.1  kalirin isoform X21

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2331 → 2387
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  32. XM_017317074.2 → XP_017172563.1  kalirin isoform X30

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (12) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2298 → 2354
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2227 → 2279
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2081 → 2215
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1907 → 2076
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1862
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  33. XM_030249190.1 → XP_030105050.1  kalirin isoform X25

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2329 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2258 → 2310
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2112 → 2246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1938 → 2107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  34. XM_030249192.1 → XP_030105052.1  kalirin isoform X29

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (12) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2299 → 2355
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2228 → 2280
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2082 → 2216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1908 → 2077
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1863
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  35. XM_017317072.3 → XP_017172561.1  kalirin isoform X22

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  36. XM_011245967.3 → XP_011244269.1  kalirin isoform X24

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (11) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2330 → 2386
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2259 → 2311
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2113 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1939 → 2108
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1929
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  37. XM_017317073.2 → XP_017172562.1  kalirin isoform X26

    UniProtKB/TrEMBL
    F6QYT9
    Conserved Domains (12) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1657 → 1716
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2329 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam04554
    Location:2258 → 2310
    Extensin_2; Extensin-like region
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2112 → 2246
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1938 → 2107
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1714 → 1928
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  38. XM_017317082.3 → XP_017172571.1  kalirin isoform X44

    UniProtKB/TrEMBL
    D3Z534
    Conserved Domains (5) summary
    cd11853
    Location:594 → 650
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:523 → 575
    Extensin_2; Extensin-like region
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23 → 158
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  39. XM_017317080.3 → XP_017172569.1  kalirin isoform X42

    UniProtKB/TrEMBL
    D3Z534
    Conserved Domains (5) summary
    cd11853
    Location:595 → 651
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:523 → 575
    Extensin_2; Extensin-like region
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23 → 158
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  40. XM_017317081.3 → XP_017172570.1  kalirin isoform X43

    UniProtKB/TrEMBL
    D3Z534
    Conserved Domains (5) summary
    cd11853
    Location:595 → 651
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:524 → 576
    Extensin_2; Extensin-like region
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23 → 159
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  41. XM_017317079.3 → XP_017172568.1  kalirin isoform X41

    UniProtKB/TrEMBL
    D3Z534
    Related
    ENSMUSP00000110615.2, ENSMUST00000114964.8
    Conserved Domains (5) summary
    cd11853
    Location:596 → 652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    pfam04554
    Location:524 → 576
    Extensin_2; Extensin-like region
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:23 → 159
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  42. XM_017317076.3 → XP_017172565.1  kalirin isoform X38

    UniProtKB/TrEMBL
    B1B1A7
    Conserved Domains (5) summary
    smart00150
    Location:1121 → 1221
    SPEC; Spectrin repeats
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1270 → 1440
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:886 → 1115
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1447 → 1569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  43. XM_017317075.3 → XP_017172564.1  kalirin isoform X37

    UniProtKB/TrEMBL
    B1B1A7
    Conserved Domains (5) summary
    smart00150
    Location:1130 → 1230
    SPEC; Spectrin repeats
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1279 → 1449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:545 → 761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1456 → 1578
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  44. XM_006522383.5 → XP_006522446.1  kalirin isoform X36

    UniProtKB/TrEMBL
    B1B1A7
    Conserved Domains (5) summary
    smart00150
    Location:1134 → 1234
    SPEC; Spectrin repeats
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1283 → 1453
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1128
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1460 → 1582
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  45. XM_011245968.4 → XP_011244270.1  kalirin isoform X34

    UniProtKB/TrEMBL
    B1B1A7
    Conserved Domains (6) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    smart00516
    Location:47 → 185
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1292 → 1462
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:899 → 1137
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1469 → 1591
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    TIGR02168
    Location:753 → 999
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  46. XM_006522382.5 → XP_006522445.1  kalirin isoform X35

    UniProtKB/TrEMBL
    B1B1A7
    Related
    ENSMUSP00000087084.6, ENSMUST00000089655.12
    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

RNA

  1. XR_001781845.2 RNA Sequence

  2. XR_001781844.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2CG49.1 GenPept UniProtKB/Swiss-Prot:A2CG49

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