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WDR5B WD repeat domain 5B [ Homo sapiens (human) ]

Gene ID: 54554, updated on 5-Sep-2021

Summary

Official Symbol
WDR5Bprovided by HGNC
Official Full Name
WD repeat domain 5Bprovided by HGNC
Primary source
HGNC:HGNC:17826
See related
Ensembl:ENSG00000196981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See WDR5B in Genome Data Viewer
Location:
3q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122411846..122416062, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122130693..122134909, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cystatin A Neighboring gene HNF4 motif-containing MPRA enhancer 1/2 Neighboring gene mitochondrial matrix import factor 23 Neighboring gene family with sequence similarity 162 member A Neighboring gene WDR5B divergent transcript Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC107984000

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11287, MGC49879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019069.4NP_061942.2  WD repeat-containing protein 5B

    See identical proteins and their annotated locations for NP_061942.2

    Status: REVIEWED

    Source sequence(s)
    AA310178, AA587370, AC083798, BC025762, BC043494, BU678251
    Consensus CDS
    CCDS3012.1
    UniProtKB/Swiss-Prot
    Q86VZ2
    Related
    ENSP00000330381.4, ENST00000330689.6
    Conserved Domains (2) summary
    cd00200
    Location:33326
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4481
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122411846..122416062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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