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MARCHF5 membrane associated ring-CH-type finger 5 [ Homo sapiens (human) ]

Gene ID: 54708, updated on 16-Apr-2024

Summary

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Official Symbol
MARCHF5provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 5provided by HGNC
Primary source
HGNC:HGNC:26025
See related
Ensembl:ENSG00000198060 MIM:610637; AllianceGenome:HGNC:26025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MITOL; MARCH5; RNF153; MARCH-V
Summary
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 13.2), prostate (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q23.32-q23.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92291167..92353964)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93173534..93236300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94050924..94113721)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2614 Neighboring gene uncharacterized LOC124902483 Neighboring gene NHP2 ribonucleoprotein pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:94051286-94051864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94065899-94066610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94066611-94067322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:94072769-94073270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:94107981-94108480 Neighboring gene NANOG hESC enhancer GRCh37_chr10:94110043-94110561 Neighboring gene RNY3 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2616 Neighboring gene uncharacterized LOC124902484 Neighboring gene MARK2 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. Lei W, et al. J Cell Mol Med, 2021 Apr. PMID 33611830, Free PMC Article
  2. Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. Koyano F, et al. EMBO Rep, 2019 Dec 5. PMID 31602805, Free PMC Article
  3. MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells. Hu J, et al. Autophagy, 2017 Feb. PMID 27875077, Free PMC Article
  4. Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control. Kim SH, et al. FEBS J, 2016 Jan. PMID 26476016
  5. A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein. Sugiura A, et al. Mitochondrion, 2011 Jan. PMID 20851218

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
    Title: PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
  2. A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.
    Title: A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.
  3. MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer.
    Title: MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer.
  4. Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
    Title: Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
  5. Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.
    Title: Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.
  6. The XBP1MARCH5MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
    Title: The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
  7. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
    Title: MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
  8. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
    Title: MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
  9. MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway.
    Title: MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway.
  10. MITOL-dependent ubiquitylation negatively regulates the entry of PolgammaA into mitochondria.
    Title: MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF5
Names
E3 ubiquitin-protein ligase MARCH5
RING-type E3 ubiquitin transferase MARCH5
RING-type E3 ubiquitin transferase MARCHF5
membrane associated ring finger 5
membrane-associated RING finger protein 5
membrane-associated RING-CH protein V
membrane-associated ring finger (C3HC4) 5
mitochondrial ubiquitin ligase
ring finger protein 153
NP_060294.1
XP_047281338.1
XP_054222122.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017824.5 → NP_060294.1  E3 ubiquitin-protein ligase MARCHF5

    See identical proteins and their annotated locations for NP_060294.1

    Status: VALIDATED

    Source sequence(s)
    AK000452, BC015480, BE393612
    Consensus CDS
    CCDS7420.1
    UniProtKB/Swiss-Prot
    Q9NX47
    Related
    ENSP00000351813.2, ENST00000358935.3
    Conserved Domains (1) summary
    cd16701
    Location:12 → 72
    RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    92291167..92353964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425382.1 → XP_047281338.1  E3 ubiquitin-protein ligase MARCHF5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    93173534..93236300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366147.1 → XP_054222122.1  E3 ubiquitin-protein ligase MARCHF5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NX47.1 GenPept UniProtKB/Swiss-Prot:Q9NX47

Gene LinkOut

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