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Fcmr Fc mu receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 548326, updated on 11-Apr-2024

Summary

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Official Symbol
Fcmrprovided by RGD
Official Full Name
Fc mu receptorprovided by RGD
Primary source
RGD:1359282
See related
Ensembl:ENSRNOG00000004441 AllianceGenome:RGD:1359282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Toso; Faim3; IgM FcR
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in immune system process. Predicted to act upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human FCMR (Fc fragment of IgM receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 267.7), Thymus (RPKM 47.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44889628..44903926)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42337363..42351706)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47602701..47617065)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Fc alpha and mu receptor Neighboring gene polymeric immunoglobulin receptor Neighboring gene interleukin 24 Neighboring gene interleukin 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. Song Y, et al. J Biol Chem, 2005 Mar 11. PMID 15632112
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables IgM binding ISO
Inferred from Sequence Orthology
more info
  
enables IgM binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables high-affinity IgM receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables high-affinity IgM receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables polymeric immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables polymeric immunoglobulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Fc receptor-mediated immune complex endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in Fc receptor-mediated immune complex endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
  
involved_in humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immunoglobulin transcytosis in epithelial cells ISO
Inferred from Sequence Orthology
more info
  
involved_in immunoglobulin transcytosis in epithelial cells ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
immunoglobulin mu Fc receptor
Names
Fas apoptotic inhibitory molecule 3
Fc fragment of IgM receptor
IgM Fc fragment receptor
regulator of Fas-induced apoptosis Toso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014843.2 → NP_001014843.1  immunoglobulin mu Fc receptor precursor

    See identical proteins and their annotated locations for NP_001014843.1

    Status: VALIDATED

    Source sequence(s)
    BC088197, JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q5M871
    UniProtKB/TrEMBL
    A0A8I5ZSV7
    Related
    ENSRNOP00000036615.5, ENSRNOT00000038822.6
    Conserved Domains (2) summary
    cd05716
    Location:27 → 120
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25 → 121
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    44889628..44903926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249715.5 → XP_006249777.1  immunoglobulin mu Fc receptor isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHV3, A6IC06
    Conserved Domains (2) summary
    cd05716
    Location:48 → 141
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:46 → 142
    IG_like; Immunoglobulin like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M871.1 GenPept UniProtKB/Swiss-Prot:Q5M871

Gene LinkOut

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