fgfr4 fibroblast growth factor receptor 4 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: fgfr4provided by Xenbase
Official Full Name: fibroblast growth factor receptor 4provided by Xenbase
Primary source: Xenbase:XB-GENE-478699
See related: Ensembl:ENSXETG00000007231
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: tkf; jtk2; cd334; fgfr-4; xfgfr4; XFGFR-4; fgfr4-a; fgfr4-b; XFGFR-4a
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (46320426..46333147, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (36841955..36854648, complement)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor receptor 4

Names: FGF receptor 4

NP_001016323.1

EC 2.7.10.1

XP_012814458.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001016323.1 → NP_001016323.1 fibroblast growth factor receptor 4 precursor

See identical proteins and their annotated locations for NP_001016323.1

Status: PROVISIONAL

Source sequence(s)

CR761450

UniProtKB/TrEMBL

B1WB19, Q28GC1

Conserved Domains (8) summary

cd05099
Location:472 → 785

PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4

cd05857
Location:175 → 259

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:282 → 369

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:55 → 121

IG; Immunoglobulin

smart00410
Location:274 → 368

IG_like; Immunoglobulin like

pfam07679
Location:172 → 259

I-set; Immunoglobulin I-set domain

pfam07714
Location:485 → 761

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:53 → 119

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

46320426..46333147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012959004.3 → XP_012814458.2 fibroblast growth factor receptor 4 isoform X1

UniProtKB/TrEMBL

B1WB19, F6VYS9

Related

ENSXETP00000015723.5, ENSXETT00000015723.5

Conserved Domains (4) summary

cd05099
Location:495 → 808

PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4

cd00096
Location:290 → 293

Ig; Ig strand A [structural motif]

cd05857
Location:188 → 282

IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains

cl11960
Location:290 → 392

Ig; Immunoglobulin domain