neil3 nei-like DNA glycosylase 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: neil3provided by Xenbase
Official Full Name: nei-like DNA glycosylase 3provided by Xenbase
Primary source: Xenbase:XB-GENE-1001611
See related: Ensembl:ENSXETG00000030606
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (47295328..47309223, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (38055196..38069116, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified neil3 as a component of the rax genetic pathway necessary for normal retinal progenitor cell development. neil3 is involved in the base excision DNA repair pathway, suggesting that this pathway is essential for normal rax-dependent progenitor cell development in the mature retina.
Title: Identification of retinal homeobox (rax) gene-dependent genes by a microarray approach: The DNA endoglycosylase neil3 is a major downstream component of the rax genetic pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endonuclease 8-like 3

Names: nei endonuclease VIII-like 3

NP_001017201.1

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017201.2 → NP_001017201.1 endonuclease 8-like 3

See identical proteins and their annotated locations for NP_001017201.1

Status: PROVISIONAL

Source sequence(s)

CR760525

UniProtKB/TrEMBL

A0A6I8Q015, Q28I93

Related

ENSXETP00000062127.3, ENSXETT00000065000.3

Conserved Domains (6) summary

cd08969
Location:1 → 134

MeNeil3_N; N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)

PRK10445
Location:1 → 263

PRK10445; endonuclease VIII; Provisional

sd00029
Location:304 → 323

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:300 → 328

zf-RanBP; Zn-finger in Ran binding protein and others

pfam06831
Location:140 → 189

H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

pfam06839
Location:530 → 571

zf-GRF; GRF zinc finger