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AGGF1 angiogenic factor with G-patch and FHA domains 1 [ Homo sapiens (human) ]

Gene ID: 55109, updated on 5-Mar-2024

Summary

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Official Symbol
AGGF1provided by HGNC
Official Full Name
angiogenic factor with G-patch and FHA domains 1provided by HGNC
Primary source
HGNC:HGNC:24684
See related
Ensembl:ENSG00000164252 MIM:608464; AllianceGenome:HGNC:24684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971
Summary
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

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See AGGF1 in Genome Data Viewer
Location:
5q13.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (77030404..77065234)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77512128..77546904)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76326229..76361059)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein Z Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76249596-76250282 Neighboring gene RNA, U6atac small nuclear 36, pseudogene Neighboring gene corticotropin releasing hormone binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76382768-76383369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76383370-76383972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76383973-76384573 Neighboring gene ZBED3 antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene uncharacterized LOC124901008 Neighboring gene zinc finger BED-type containing 3 Neighboring gene phosphodiesterase 8B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AGGF1 inhibits the expression of inflammatory mediators and promotes angiogenesis in dental pulp cells. Shen S, et al. Clin Oral Investig, 2021 Feb. PMID 32789654
  2. Angiogenic factor with G patch and FHA domains 1 protects retinal vascular endothelial cells under hyperoxia by inhibiting autophagy. Yao G, et al. J Biochem Mol Toxicol, 2020 Nov. PMID 32633013
  3. Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis. Wang W, et al. Med Sci Monit, 2020 Feb 24. PMID 32090983, Free PMC Article
  4. Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer. Zhang X, et al. BMC Cancer, 2019 Dec 27. PMID 31881864, Free PMC Article
  5. LncRNA OR3A4 participates in the angiogenesis of hepatocellular carcinoma through modulating AGGF1/akt/mTOR pathway. Li W, et al. Eur J Pharmacol, 2019 Apr 15. PMID 30710550

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
    Title: Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
  2. Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.
    Title: Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.
  3. Angiogenic factor with G patch and FHA domains 1 protects retinal vascular endothelial cells under hyperoxia by inhibiting autophagy.
    Title: Angiogenic factor with G patch and FHA domains 1 protects retinal vascular endothelial cells under hyperoxia by inhibiting autophagy.
  4. Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2.
    Title: Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2.
  5. AGGF1 inhibits the expression of inflammatory mediators and promotes angiogenesis in dental pulp cells.
    Title: AGGF1 inhibits the expression of inflammatory mediators and promotes angiogenesis in dental pulp cells.
  6. Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis.
    Title: Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis.
  7. At the protein level, AGGF1 expression in colorectal cancer (CRC) tissues was higher than in paired normal mucosa, which showed a clear association with TNM stage, AJCC stage, vascular invasion, and differentiation. An apparent correlation between AGGF1 expression and poorer disease-free survival and overall survival of CRC patients was revealed.
    Title: Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer.
  8. LncRNA OR3A4 participates in the angiogenesis of hepatocellular carcinoma through modulating AGGF1/akt/mTOR pathway
    Title: LncRNA OR3A4 participates in the angiogenesis of hepatocellular carcinoma through modulating AGGF1/akt/mTOR pathway.
  9. Aggf1 has a role in regulating vascular injury.
    Title: Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.
  10. High expression of AGGF1 predicts poor prognosis in gastric cancer patients.
    Title: High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vasculogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
angiogenic factor with G patch and FHA domains 1
Names
G patch domain-containing protein 7
angiogenic factor VG5Q
vasculogenesis gene on 5q protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027822.1 RefSeqGene

    Range
    5020..39850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018046.5 → NP_060516.2  angiogenic factor with G patch and FHA domains 1

    See identical proteins and their annotated locations for NP_060516.2

    Status: REVIEWED

    Source sequence(s)
    AC008581, AI453097, AY500994, BI561566, BX648120, DR157679
    Consensus CDS
    CCDS4035.1
    UniProtKB/Swiss-Prot
    O00581, Q53YS3, Q8N302, Q9BU84, Q9NW66
    UniProtKB/TrEMBL
    Q6PIK7
    Related
    ENSP00000316109.7, ENST00000312916.12
    Conserved Domains (4) summary
    COG1196
    Location:22 → 87
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00060
    Location:410 → 516
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd16164
    Location:200 → 253
    OCRE_VG5Q; OCRE domain found in angiogenic factor VG5Q and similar proteins
    pfam01585
    Location:620 → 661
    G-patch; G-patch domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    77030404..77065234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77512128..77546904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013303.1: Suppressed sequence

    Description
    NM_013303.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_138490.1: Suppressed sequence

    Description
    NM_138490.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N302.2 GenPept UniProtKB/Swiss-Prot:Q8N302

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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