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TMEM33 transmembrane protein 33 [ Homo sapiens (human) ]

Gene ID: 55161, updated on 7-Apr-2024

Summary

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Official Symbol
TMEM33provided by HGNC
Official Full Name
transmembrane protein 33provided by HGNC
Primary source
HGNC:HGNC:25541
See related
Ensembl:ENSG00000109133 MIM:618515; AllianceGenome:HGNC:25541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pom33; SHINC3; SHINC-3; 1600019D15Rik
Summary
Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41935137..41960803)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41908187..41934614)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41937446..41962820)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41910569-41911460 Neighboring gene uncharacterized LOC105374426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:41914902-41916101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21510 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:41983504-41984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21511 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41992428-41992647 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene solute carrier family 30 member 9 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. Liu F, et al. EMBO J, 2021 Nov 15. PMID 34487377, Free PMC Article
  2. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Sakabe I, et al. Breast Cancer Res Treat, 2015 Sep. PMID 26268696, Free PMC Article
  3. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, et al. Nat Commun, 2019 May 2. PMID 31048699, Free PMC Article
  4. Identification and characterization of TMEM33 as a reticulon-binding protein. Urade T, et al. Kobe J Med Sci, 2014 Nov 6. PMID 25612671
  5. Purification and identification of G protein-coupled receptor protein complexes under native conditions. Daulat AM, et al. Mol Cell Proteomics, 2007 May. PMID 17215244

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
    Title: PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
  2. TMEM33 is a novel regulator of the PERK-eIE2alpha-ATF4 and IRE1-XBP1 axes of the UPR signaling.
    Title: TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transmembrane protein 33 (TMEM33) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of IRE1-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of PERK-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endoplasmic reticulum tubular network organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018126.3 → NP_060596.2  transmembrane protein 33

    See identical proteins and their annotated locations for NP_060596.2

    Status: VALIDATED

    Source sequence(s)
    AC106052, BC000948
    Consensus CDS
    CCDS3464.1
    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000422473.1, ENST00000504986.6
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    41935137..41960803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248116.5 → XP_005248173.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248173.1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000422810.1, ENST00000508448.5
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

  2. XM_005248117.3 → XP_005248174.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248174.1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000427006.1, ENST00000513702.5
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    41908187..41934614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350372.1 → XP_054206347.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953

  2. XM_054350370.1 → XP_054206345.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953

  3. XM_054350371.1 → XP_054206346.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57088.2 GenPept UniProtKB/Swiss-Prot:P57088

Gene LinkOut

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