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sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [ Danio rerio (zebrafish) ]

Gene ID: 553130, updated on 11-Apr-2024

Summary

Official Symbol
sema3cprovided by ZNC
Official Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050513-5
See related
Ensembl:ENSDARG00000034300 AllianceGenome:ZFIN:ZDB-GENE-050513-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-105o6.1
Summary
Enables neuropilin binding activity. Acts upstream of or within enteric nervous system development. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in caudal tuberculum and otic vesicle. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See sema3c in Genome Data Viewer
Location:
chromosome: 4
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22572255..22656266)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22892648..22935293)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene lysine (K)-specific demethylase 7Aa Neighboring gene CD36 molecule (CD36 blood group) Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropilin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
semaphorin-3C
Names
semaphorin 3c

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    22572255..22656266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017355318.2XP_017210807.2  semaphorin-3C

    UniProtKB/TrEMBL
    A0A8M6Z658
    Related
    ENSDARP00000111452.2, ENSDART00000131161.3
    Conserved Domains (3) summary
    cd05871
    Location:585674
    Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
    cd11251
    Location:55524
    Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)
    smart00423
    Location:523568
    PSI; domain found in Plexins, Semaphorins and Integrins