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STRBP spermatid perinuclear RNA binding protein [ Homo sapiens (human) ]

Gene ID: 55342, updated on 7-Apr-2024

Summary

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Official Symbol
STRBPprovided by HGNC
Official Full Name
spermatid perinuclear RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16462
See related
Ensembl:ENSG00000165209 MIM:611138; AllianceGenome:HGNC:16462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p74; SPNR; ILF3L; HEL162
Summary
Enables RNA binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within mechanosensory behavior and spermatid development. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.5), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q33.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123109494..123268586, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135300815..135465770, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125883548..126030865, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125834601-125835274 Neighboring gene G protein-coupled receptor 21 Neighboring gene Sharpr-MPRA regulatory region 8358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28932 Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125937073-125937784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:126030691-126031191 Neighboring gene uncharacterized LOC105376265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126088537-126089038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126089039-126089538 Neighboring gene uncharacterized LOC124902266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28938

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome. Salemi M, et al. J Endocrinol Invest, 2012 Jan. PMID 22391137
  2. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498
  3. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
  4. A new double-stranded RNA-binding protein that interacts with PKR. Coolidge CJ, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684936, Free PMC Article
  5. Screening of LRRK2 interactants by yeast 2-hybrid analysis. Zheng XY, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008 Oct. PMID 19001729

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.
    Title: CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.
  2. Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
    Title: Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
  3. Low STRBP mRNA is associated with cryptorchidism and Down's syndrome.
    Title: Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3405, FLJ11307, FLJ14223, FLJ14984, FLJ21960, MGC21529, DKFZp434N214

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in mechanosensory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
spermatid perinuclear RNA-binding protein
Names
epididymis luminal protein 162
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171137.2 → NP_001164608.1  spermatid perinuclear RNA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001164608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR but has a downstream additional exon, which results in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the N-terminus.
    Source sequence(s)
    AL136866, AL365338, AL365504, BC002693
    Consensus CDS
    CCDS55337.1
    UniProtKB/Swiss-Prot
    Q96SI9
    Related
    ENSP00000354271.3, ENST00000360998.3
    Conserved Domains (4) summary
    smart00572
    Location:67 → 320
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:594 → 653
    SGP; Sulphur globule protein
    cd19909
    Location:370 → 453
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:498 → 561
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  2. NM_001376106.1 → NP_001363035.1  spermatid perinuclear RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    Consensus CDS
    CCDS6851.1
    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  3. NM_001376107.1 → NP_001363036.1  spermatid perinuclear RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    Consensus CDS
    CCDS6851.1
    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  4. NM_001376109.1 → NP_001363038.1  spermatid perinuclear RNA-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL365338, AL365504
    Conserved Domains (3) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  5. NM_018387.5 → NP_060857.2  spermatid perinuclear RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_060857.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL365338, AL365504, BC002693, BC017732
    Consensus CDS
    CCDS6851.1
    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Related
    ENSP00000321347.7, ENST00000348403.10
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

RNA

  1. NR_033234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has several alternate splice sites, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate.
    Source sequence(s)
    AL365338, AL365504, AL834150, BC108731

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    123109494..123268586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423563.1 → XP_047279519.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5K8

  2. XM_047423562.1 → XP_047279518.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4
    Related
    ENSP00000415968.2, ENST00000447404.6

RNA

  1. XR_007061327.1 RNA Sequence

  2. XR_007061326.1 RNA Sequence

  3. XR_001746347.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    135300815..135465770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363231.1 → XP_054219206.1  spermatid perinuclear RNA-binding protein isoform X3

  2. XM_054363230.1 → XP_054219205.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5K8

  3. XM_054363225.1 → XP_054219200.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4

  4. XM_054363229.1 → XP_054219204.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5K8

  5. XM_054363226.1 → XP_054219201.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4

  6. XM_054363228.1 → XP_054219203.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4

  7. XM_054363227.1 → XP_054219202.1  spermatid perinuclear RNA-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
    UniProtKB/TrEMBL
    V9HWK4

RNA

  1. XR_008488043.1 RNA Sequence

  2. XR_008488042.1 RNA Sequence

  3. XR_008488040.1 RNA Sequence

  4. XR_008488044.1 RNA Sequence

  5. XR_008488041.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96SI9.1 GenPept UniProtKB/Swiss-Prot:Q96SI9

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