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BRCA1 BRCA1 DNA repair associated [ Monodelphis domestica (gray short-tailed opossum) ]

Gene ID: 554178, updated on 3-Apr-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
Ensembl:ENSMODG00000015150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Monodelphis domestica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 2 NC_077228.1 (193283792..193360325)
103 previous assembly MonDom5 (GCF_000002295.2) 2 NC_008802.1 (193075219..193152046)

Chromosome 2 - NC_077228.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral. Tavtigian SV, et al. J Med Genet, 2006 Apr. PMID 16014699, Free PMC Article
  2. Nuclear gene sequences provide evidence for the monophyly of australidelphian marsupials. Amrine-Madsen H, et al. Mol Phylogenet Evol, 2003 Aug. PMID 12878458

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
breast cancer 1, early onset
breast cancer susceptibility protein
NP_001029141.1
XP_007482190.2
XP_007482191.2
XP_016284352.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033969.1 → NP_001029141.1  breast cancer type 1 susceptibility protein

    Status: PROVISIONAL

    Source sequence(s)
    AY994160
    UniProtKB/TrEMBL
    Q52P67
    Related
    ENSMODP00000018933.2, ENSMODT00000019275.3
    Conserved Domains (6) summary
    smart00292
    Location:1735 → 1819
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1634 → 1700
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam04747
    Location:1318 → 1585
    DUF612; Protein of unknown function, DUF612
    pfam12820
    Location:340 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl21456
    Location:489 → 550
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mMonDom1.pri

Genomic

  1. NC_077228.1 Reference mMonDom1.pri

    Range
    193283792..193360325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016428866.2 → XP_016284352.2  breast cancer type 1 susceptibility protein isoform X1

  2. XM_007482128.3 → XP_007482190.2  breast cancer type 1 susceptibility protein isoform X1

  3. XM_007482129.3 → XP_007482191.2  breast cancer type 1 susceptibility protein isoform X2

Nucleotide Protein
Heading Accession and Version

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