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Gpr34 G protein-coupled receptor 34 [ Rattus norvegicus (Norway rat) ]

Gene ID: 554353, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr34provided by RGD
Official Full Name
G protein-coupled receptor 34provided by RGD
Primary source
RGD:1563681
See related
Ensembl:ENSRNOG00000039759 AllianceGenome:RGD:1563681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Orthologous to human GPR34 (G protein-coupled receptor 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 44.7), Spleen (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (11777667..11786640, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (9104829..9113796, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (10022986..10043504, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon UUG) 5 Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene G protein-coupled receptor 82 Neighboring gene uncharacterized LOC120099226 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a lysophosphatidylserine receptor on mast cells. Sugo T, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16460680
  2. GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. Kitamura H, et al. J Biochem, 2012 May. PMID 22343749
  3. Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. Schuh K, et al. J Biol Chem, 2003 Mar 14. PMID 12511555
  4. The structural evolution of a P2Y-like G-protein-coupled receptor. Schulz A, et al. J Biol Chem, 2003 Sep 12. PMID 12835326
  5. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, et al. J Biol Chem, 2004 Apr 30. PMID 14960569

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position.
    Title: GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
  2. results suggest that GPR34 is the functional mast cell lysophosphatidylserine receptor
    Title: Identification of a lysophosphatidylserine receptor on mast cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024925.2 → NP_001020096.1  probable G-protein coupled receptor 34

    See identical proteins and their annotated locations for NP_001020096.1

    Status: PROVISIONAL

    Source sequence(s)
    AB159443
    UniProtKB/TrEMBL
    A0A8I6AI22, A6JZX9, Q6XCE7
    Related
    ENSRNOP00000080929.1, ENSRNOT00000106478.1
    Conserved Domains (1) summary
    cd15148
    Location:47 → 330
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    11777667..11786640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256675.5 → XP_006256737.1  probable G-protein coupled receptor 34 isoform X1

    See identical proteins and their annotated locations for XP_006256737.1

    UniProtKB/TrEMBL
    A0A8I6AI22, A6JZX9, Q6XCE7
    Related
    ENSRNOP00000080963.1
    Conserved Domains (1) summary
    cd15148
    Location:47 → 330
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_039099999.2 → XP_038955927.1  probable G-protein coupled receptor 34 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI22, A6JZX9, Q6XCE7
    Conserved Domains (1) summary
    cd15148
    Location:47 → 330
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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