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crema cAMP responsive element modulator a [ Danio rerio (zebrafish) ]

Gene ID: 555432, updated on 5-Jan-2022

Summary

Official Symbol
cremaprovided by ZNC
Official Full Name
cAMP responsive element modulator aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7031
See related
Ensembl:ENSDARG00000023217
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fk66d05; wu:fk66d05; si:dkey-177e13.4
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in brain. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See crema in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43157842..43196661, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43308712..43347236, complement)
103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (43256633..43297937, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene finTRIM family, member 14 Neighboring gene finTRIM family, member 15 Neighboring gene par-3 family cell polarity regulator alpha, b Neighboring gene neuropilin 1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cAMP-responsive element modulator
Names
Zfcrem

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    43157842..43196661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_677932.9XP_683024.3  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_683024.3

    UniProtKB/TrEMBL
    E7F9I0
    Related
    ENSDARP00000116638.1, ENSDART00000141087.2
    Conserved Domains (2) summary
    cd14690
    Location:244298
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:67105
    pKID; pKID domain
  2. XM_005171404.4XP_005171461.1  cAMP-responsive element modulator isoform X3

    UniProtKB/TrEMBL
    E9QD53
    Related
    ENSDARP00000112661.1, ENSDART00000132588.3
    Conserved Domains (1) summary
    cd14690
    Location:54108
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  3. XM_005171403.4XP_005171460.1  cAMP-responsive element modulator isoform X2

    Conserved Domains (2) summary
    cd14690
    Location:205259
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:2866
    pKID; pKID domain
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