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myh10 myosin, heavy chain 10, non-muscle [ Danio rerio (zebrafish) ]

Gene ID: 555454, updated on 22-May-2022

Summary

Official Symbol
myh10provided by ZNC
Official Full Name
myosin, heavy chain 10, non-muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-162
See related
Ensembl:ENSDARG00000000103 AllianceGenome:ZFIN:ZDB-GENE-030616-162
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dZ204D19.2; wu:fc46h07; wu:fy19d11; si:dz150i12.3
Summary
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to be part of myosin complex. Is expressed in several structures, including nervous system; neural tube; paraxial mesoderm; swim bladder bud; and tail bud. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See myh10 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
44
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7553078..7658287)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7395905..7501116)
103 previous assembly Zv9 (GCF_000002035.4) 6 NC_007117.5 (7469881..7575102)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 3a Neighboring gene proliferation-associated 2G4, a Neighboring gene ubinuclein 2a Neighboring gene tetratricopeptide repeat domain 26

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament bundle distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myosin-10
Names
myosin, heavy polypeptide 10, non-muscle
nm-mhc-b
nonmuscle myosin heavy chain B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    7553078..7658287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302145.3XP_009300420.1  myosin-10 isoform X1

    Conserved Domains (8) summary
    cd14920
    Location:102812
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90812
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8891969
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:17051714
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10851170
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16411734
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:15281637
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_009302146.3XP_009300421.1  myosin-10 isoform X2

    Conserved Domains (8) summary
    cd14920
    Location:102806
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90806
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8831963
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16991708
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10791164
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16351728
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:15221631
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_009302147.3XP_009300422.1  myosin-10 isoform X3

    Conserved Domains (8) summary
    cd14920
    Location:102796
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90796
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8731953
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16891698
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10691154
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16251718
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:15121621
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. XM_009302149.3XP_009300424.1  myosin-10 isoform X4

    UniProtKB/TrEMBL
    F1R3G4
    Related
    ENSDARP00000125918.1, ENSDART00000151114.2
    Conserved Domains (8) summary
    cd14920
    Location:102790
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90790
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8671947
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16831692
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10631148
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16191712
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:15061615
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. XM_005165720.4XP_005165777.1  myosin-10 isoform X5

    UniProtKB/TrEMBL
    I3ISA3
    Related
    ENSDARP00000125771.1, ENSDART00000150939.3
    Conserved Domains (8) summary
    cd14920
    Location:102784
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90784
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8611941
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16771686
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10571142
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16131706
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:15001607
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  6. XM_677954.9XP_683046.6  myosin-10 isoform X6

    Conserved Domains (8) summary
    cd14920
    Location:102774
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90774
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8511931
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3775
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16671676
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:10471132
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:16031696
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:14901597
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)