ZNF692 zinc finger protein 692 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF692provided by HGNC
Official Full Name: zinc finger protein 692provided by HGNC
Primary source: HGNC:HGNC:26049
See related: Ensembl:ENSG00000171163 MIM:617758; AllianceGenome:HGNC:26049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AREBP; Zfp692
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis (RPKM 9.4), prostate (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q44

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (248850008..248859085, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (248288491..248297596, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (249144207..249153284, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.
Title: ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.
ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway.
Title: ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway.
Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma.
Title: Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma.
Results found that ZNF692 was upregulated in colon adenocarcinoma (COAD) tissues and cells and that high ZNF692 expression was significantly correlated with lymph node metastasis, distant metastasis and tumor stage in COAD patients. Furthermore, ZNF692 promoted COAD cell proliferation, migration and invasion via the PI3K/AKT pathway, suggesting that ZNF692 may serve as a novel oncogene for COAD.
Title: ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway.
ZNF692 promotes CC cells proliferation and invasion through suppressing p27(kip1) transcription by directly binding its promoter region.
Title: A clinical, biologic and mechanistic analysis of the role of ZNF692 in cervical cancer.
The results show that ZNF692 is expressed in LUAD tissues compared to adjacent normal tissues, and hyper-expression of ZNF692 in LUAD is an independent risk factor for worse overall survival in LUAD patients (HR: 8.800, 95%CI: 1.082-71.560, P = 0.042) by Tissue Microarray stain assay (TMA).
Title: ZNF692 promotes proliferation and cell mobility in lung adenocarcinoma.
cloning and characterization of a novel zinc finger transcription factor referred to as AREBP. AREBP is phosphorylated at Ser(470) by AMPK.
Title: AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-76656 (e-PCR)
- UniSTS:39551

D1S3739 (e-PCR)
- UniSTS:52154

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: zinc finger protein 692

Names: AICAR responsive element binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136036.3 → NP_001129508.1 zinc finger protein 692 isoform 1

See identical proteins and their annotated locations for NP_001129508.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK302187, AL672291, DA147512, DB520788, H07076

Consensus CDS

CCDS44348.1

UniProtKB/Swiss-Prot

Q9BU19

Related

ENSP00000391200.1, ENST00000451251.5

Conserved Domains (4) summary

COG5048
Location:389 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:366 → 388

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:394 → 416

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:408 → 433

zf-H2C2_2; Zinc-finger double domain
NM_001193328.2 → NP_001180257.1 zinc finger protein 692 isoform 3

See identical proteins and their annotated locations for NP_001180257.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains a different first exon, which results in the use of a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.

Source sequence(s)

AK225535, AK302187, H07076

Consensus CDS

CCDS53487.1

UniProtKB/Swiss-Prot

Q9BU19

Related

ENSP00000355427.3, ENST00000366471.7

Conserved Domains (3) summary

sd00017
Location:316 → 338

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:344 → 366

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:358 → 383

zf-H2C2_2; Zinc-finger double domain
NM_001350072.2 → NP_001337001.1 zinc finger protein 692 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains a different first exon, which results in the use of a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus and lacks an internal aa when it is compared to isoform 1.

Source sequence(s)

BC002948, DA319079

Conserved Domains (4) summary

COG5189
Location:289 → 407

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:357 → 484

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:360 → 382

ZF_C2H2; C2H2 Zn finger [structural motif]

cl26386
Location:208 → 332

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
NM_001350073.2 → NP_001337002.1 zinc finger protein 692 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains a different first exon, and uses alternate splice sites at another exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.

Source sequence(s)

AL672291, BC002948, DA319079, DA765600

UniProtKB/TrEMBL

H0YCH4

Conserved Domains (4) summary

COG5189
Location:86 → 204

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:154 → 281

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:157 → 179

ZF_C2H2; C2H2 Zn finger [structural motif]

cl25580
Location:4 → 121

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_017865.4 → NP_060335.2 zinc finger protein 692 isoform 2

See identical proteins and their annotated locations for NP_060335.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different first exon, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.

Source sequence(s)

BC002948, DA319079

Consensus CDS

CCDS31127.1

UniProtKB/Swiss-Prot

B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97

Related

ENSP00000305483.5, ENST00000306601.9

Conserved Domains (4) summary

COG5189
Location:290 → 408

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:358 → 485

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:361 → 383

ZF_C2H2; C2H2 Zn finger [structural motif]

cl25580
Location:208 → 325

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

248850008..248859085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047424581.1 → XP_047280537.1 zinc finger protein 692 isoform X7
XM_017001698.2 → XP_016857187.1 zinc finger protein 692 isoform X4

Conserved Domains (4) summary

COG5189
Location:289 → 407

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:357 → 484

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:360 → 382

ZF_C2H2; C2H2 Zn finger [structural motif]

cl26386
Location:208 → 332

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
XM_017001700.2 → XP_016857189.1 zinc finger protein 692 isoform X6
XM_011544222.2 → XP_011542524.1 zinc finger protein 692 isoform X3

See identical proteins and their annotated locations for XP_011542524.1

UniProtKB/Swiss-Prot

B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97

Conserved Domains (4) summary

COG5189
Location:290 → 408

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:358 → 485

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:361 → 383

ZF_C2H2; C2H2 Zn finger [structural motif]

cl25580
Location:208 → 325

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
XM_011544221.3 → XP_011542523.2 zinc finger protein 692 isoform X2

UniProtKB/TrEMBL

H0YCH4

Conserved Domains (5) summary

COG5048
Location:179 → 280

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:156 → 178

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:198 → 223

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:124 → 202

zf-C2H2_8; C2H2-type zinc ribbon

cl25580
Location:4 → 120

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
XM_017001699.3 → XP_016857188.2 zinc finger protein 692 isoform X5

UniProtKB/TrEMBL

H0YCH4

Related

ENSP00000431582.1, ENST00000476503.5

Conserved Domains (3) summary

COG5189
Location:62 → 178

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:128 → 255

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:131 → 153

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011544220.3 → XP_011542522.2 zinc finger protein 692 isoform X1

UniProtKB/TrEMBL

H0YCH4

Conserved Domains (4) summary

COG5189
Location:86 → 204

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:154 → 281

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:157 → 179

ZF_C2H2; C2H2 Zn finger [structural motif]

cl25580
Location:4 → 121

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
XM_047424596.1 → XP_047280552.1 zinc finger protein 692 isoform X10
XM_017001702.3 → XP_016857191.1 zinc finger protein 692 isoform X6
XM_047424586.1 → XP_047280542.1 zinc finger protein 692 isoform X9
XM_047424599.1 → XP_047280555.1 zinc finger protein 692 isoform X1
XM_024448274.2 → XP_024304042.1 zinc finger protein 692 isoform X1

UniProtKB/TrEMBL

H0YCH4

Conserved Domains (4) summary

COG5189
Location:86 → 204

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

COG5236
Location:154 → 281

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:157 → 179

ZF_C2H2; C2H2 Zn finger [structural motif]

cl25580
Location:4 → 121

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
XM_011544227.2 → XP_011542529.1 zinc finger protein 692 isoform X9

See identical proteins and their annotated locations for XP_011542529.1

Conserved Domains (4) summary

COG5048
Location:357 → 458

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:334 → 356

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:362 → 384

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:376 → 401

zf-H2C2_2; Zinc-finger double domain
XM_047424603.1 → XP_047280559.1 zinc finger protein 692 isoform X1

Related

ENST00000533927.5
XM_047424583.1 → XP_047280539.1 zinc finger protein 692 isoform X8