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lgals3a lectin, galactoside binding soluble 3a [ Danio rerio (zebrafish) ]

Gene ID: 557373, updated on 27-Mar-2024

Summary

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Official Symbol
lgals3aprovided by ZNC
Official Full Name
lectin, galactoside binding soluble 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7667
See related
Ensembl:ENSDARG00000077850 AllianceGenome:ZFIN:ZDB-GENE-030131-7667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lgals3; fb13c09; fk60g08; si:ch211-67f24.5
Summary
Predicted to enable IgE binding activity and laminin binding activity. Predicted to be involved in several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of calcium ion import. Predicted to act upstream of or within RNA splicing; innate immune response; and mRNA processing. Predicted to be located in extracellular region. Predicted to be part of spliceosomal complex. Predicted to be active in several cellular components, including extracellular space; immunological synapse; and nucleus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36568633..36582393, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36442803..36456562, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene desumoylating isopeptidase 2-like Neighboring gene synaptojanin 2 binding protein Neighboring gene glia maturation factor, beta Neighboring gene cornichon family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Correlated expression of retrocopies and parental genes in zebrafish. Zhong Z, et al. Mol Genet Genomics, 2016 Apr. PMID 26561303
  2. npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Wiweger M, et al. Front Cell Neurosci, 2021. PMID 33986646, Free PMC Article
  3. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
  4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables IgE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables disaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in immunological synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
galectin-3; basic proline-rich protein
Names
lectin, galactoside-binding, soluble, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386796.1 → NP_001373725.1  galectin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX927407
    UniProtKB/TrEMBL
    A0A8N7UTJ9
    Conserved Domains (2) summary
    smart00908
    Location:246 → 362
    Gal-bind_lectin; Galactoside-binding lectin
    PRK07764
    Location:11 → 158
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  2. NM_001386797.1 → NP_001373726.1  galectin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX927407
    UniProtKB/TrEMBL
    A0A8M2B3V2
    Conserved Domains (1) summary
    PRK07764
    Location:26 → 241
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    36568633..36582393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_699180.9 → XP_704272.2  galectin-3 isoform X1

    Related
    ENSDARP00000100661.3, ENSDART00000113204.4
    Conserved Domains (2) summary
    smart00908
    Location:246 → 362
    Gal-bind_lectin; Galactoside-binding lectin
    PRK07764
    Location:11 → 158
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  2. XM_005157026.3 → XP_005157083.1  basic proline-rich protein isoform X2

    Conserved Domains (1) summary
    PRK07764
    Location:26 → 241
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
Nucleotide Protein Strain
Heading Accession and Version

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