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bmp7b bone morphogenetic protein 7b [ Danio rerio (zebrafish) ]

Gene ID: 557567, updated on 5-Jan-2022

Summary

Official Symbol
bmp7bprovided by ZNC
Official Full Name
bone morphogenetic protein 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-328
See related
Ensembl:ENSDARG00000063230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153025
Summary
Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in BMP signaling pathway; SMAD protein signal transduction; and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; fin; neuroepithelial cell; optic cup; and sensory system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See bmp7b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (6421407..6522567, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (6487436..6588548, complement)
103 previous assembly Zv9 (GCF_000002035.4) 23 NC_007134.5 (6472221..6573031, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IIa Neighboring gene protein phosphatase 1 regulatory subunit 12B-like Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene RNA binding motif protein 38

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein 7; bone morphogenetic protein 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077146.2NP_001070614.2  bone morphogenetic protein 7b

    Status: VALIDATED

    Source sequence(s)
    BX323087, CR339064
    Related
    ENSDARP00000086646.3, ENSDART00000092214.5
    Conserved Domains (2) summary
    pfam00019
    Location:326426
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:32274
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    6421407..6522567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174107.4XP_005174164.1  bone morphogenetic protein 7 isoform X1

    UniProtKB/TrEMBL
    F1QD07
    Related
    ENSDARP00000119798.1, ENSDART00000138020.2
    Conserved Domains (2) summary
    pfam00019
    Location:326426
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:32274
    TGFb_propeptide; TGF-beta propeptide
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