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adcy2b adenylate cyclase 2b (brain) [ Danio rerio (zebrafish) ]

Gene ID: 557902, updated on 11-Apr-2024

Summary

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Official Symbol
adcy2bprovided by ZNC
Official Full Name
adenylate cyclase 2b (brain)provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-69
See related
Ensembl:ENSDARG00000014588 AllianceGenome:ZFIN:ZDB-GENE-060503-69
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-266i6.1
Summary
Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cAMP biosynthetic process and intracellular signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See adcy2b in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (27609618..27776856, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (28025395..28192692, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-46h3.2 Neighboring gene cilia and flagella associated protein 90 Neighboring gene terminal nucleotidyltransferase 4A Neighboring gene steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
  2. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. Nakao T, et al. PLoS One, 2012. PMID 22485131, Free PMC Article
  3. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971
  4. Organization of Iroquois genes in fish. Dildrop R, et al. Dev Genes Evol, 2004 Jun. PMID 15133664
  5. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylate cyclase type 2; adenylate cyclase type 2b
NP_001093457.1
XP_005170095.1
XP_021323758.1
XP_021323759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099987.1 → NP_001093457.1  adenylate cyclase type 2b

    Status: PROVISIONAL

    Source sequence(s)
    BX511155, CR759914
    UniProtKB/TrEMBL
    A0A8M1NDL5, Q1L8K1
    Related
    ENSDARP00000119823.1, ENSDART00000135348.3
    Conserved Domains (4) summary
    smart00044
    Location:283 → 486
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:926 → 1125
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:542 → 643
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:80 → 307
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    27609618..27776856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170038.4 → XP_005170095.1  adenylate cyclase type 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHB8, F1Q5J6
    Related
    ENSDARP00000046165.6, ENSDART00000046166.9
    Conserved Domains (4) summary
    smart00044
    Location:283 → 486
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:929 → 1128
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:542 → 646
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:80 → 307
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. XM_021468083.1 → XP_021323758.1  adenylate cyclase type 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PB02
    Conserved Domains (2) summary
    pfam00211
    Location:599 → 798
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:212 → 316
    DUF1053; Domain of Unknown Function (DUF1053)

  3. XM_021468084.1 → XP_021323759.1  adenylate cyclase type 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PGG7
    Conserved Domains (3) summary
    pfam00211
    Location:328 → 512
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:542 → 646
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:80 → 307
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RNA

  1. XR_002456106.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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