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Bri3 brain protein I3 [ Mus musculus (house mouse) ]

Gene ID: 55950, updated on 7-Apr-2024

Summary

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Official Symbol
Bri3provided by MGI
Official Full Name
brain protein I3provided by MGI
Primary source
MGI:MGI:1933174
See related
Ensembl:ENSMUSG00000047843 AllianceGenome:MGI:1933174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I3; Gm38675
Summary
Predicted to enable identical protein binding activity. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Is expressed in pituitary gland. Orthologous to human BRI3 (brain protein I3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 96.2), adrenal adult (RPKM 87.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5; 5 G2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144181247..144383567)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144244437..144264573)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2183 Neighboring gene RIKEN cDNA 2900089D17 gene Neighboring gene BAI1-associated protein 2-like 1 Neighboring gene predicted gene 15708 Neighboring gene STARR-seq mESC enhancer starr_14808 Neighboring gene Dmrt1 interacting ncRNA Neighboring gene STARR-seq mESC enhancer starr_14810 Neighboring gene predicted gene, 33552 Neighboring gene STARR-seq mESC enhancer starr_14811 Neighboring gene STARR-seq mESC enhancer starr_14813 Neighboring gene predicted gene, 33714 Neighboring gene predicted gene, 33765

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Wu H, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592447
  2. A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain. Kato K. Eur J Neurosci, 1990. PMID 12106288
  3. Partial transcriptome of the developing pituitary gland. Douglas KR, et al. Genomics, 2000 Dec 15. PMID 11161784
  4. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane protein BRI3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163709.2 → NP_001157181.1  membrane protein BRI3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139636
    Consensus CDS
    CCDS51694.1
    UniProtKB/TrEMBL
    E9PUB2
    Related
    ENSMUSP00000106323.2, ENSMUST00000110695.8
    Conserved Domains (1) summary
    pfam10164
    Location:40 → 120
    DUF2367; Uncharacterized conserved protein (DUF2367)

  2. NM_018772.5 → NP_061242.3  membrane protein BRI3 isoform 1

    See identical proteins and their annotated locations for NP_061242.3

    Status: VALIDATED

    Source sequence(s)
    AC139636
    Consensus CDS
    CCDS19848.1
    UniProtKB/Swiss-Prot
    P28662, Q501N3, Q9Z1S1
    UniProtKB/TrEMBL
    Q8C4X5
    Related
    ENSMUSP00000057263.7, ENSMUST00000056578.7
    Conserved Domains (1) summary
    pfam10164
    Location:29 → 124
    DUF2367; Uncharacterized conserved protein (DUF2367)

RNA

  1. NR_190571.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139636

  2. NR_190572.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134523, AC139636

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144181247..144383567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165318.1 → XP_036021211.1  membrane protein BRI3 isoform X1

    UniProtKB/TrEMBL
    Q8C7X8
    Conserved Domains (1) summary
    pfam10164
    Location:29 → 82
    DUF2367; Uncharacterized conserved protein (DUF2367)

RNA

  1. XR_004942543.1 RNA Sequence

    Related
    ENSMUST00000155491.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28662.2 GenPept UniProtKB/Swiss-Prot:P28662

Gene LinkOut

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