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Car5b carbonic anhydrase 5b, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 56078, updated on 21-Apr-2024

Summary

Official Symbol
Car5bprovided by MGI
Official Full Name
carbonic anhydrase 5b, mitochondrialprovided by MGI
Primary source
MGI:MGI:1926249
See related
Ensembl:ENSMUSG00000031373 AllianceGenome:MGI:1926249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAVB; Ca5b; CarVb; 7330410H16Rik; D730005F19Rik
Summary
Enables carbonate dehydratase activity. Acts upstream of or within response to bacterium. Located in mitochondrion. Is expressed in medulla oblongata and medulla oblongata floor plate. Orthologous to human CA5B (carbonic anhydrase 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 31.5), genital fat pad adult (RPKM 23.6) and 7 other tissues See more
Orthologs
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Genomic context

Location:
X F5; X 76.03 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162759818..162811006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (163976822..164028010, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11688 Neighboring gene predicted gene, 52456 Neighboring gene adaptor-related protein complex 1, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_48235 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene predicted gene, 38561 Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene siah E3 ubiquitin protein ligase 1B Neighboring gene collectrin, amino acid transport regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonic anhydrase 5B, mitochondrial
Names
CA-VB
carbonate dehydratase VB
carbonic anhydrase VB
NP_851832.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181315.4NP_851832.2  carbonic anhydrase 5B, mitochondrial precursor

    See identical proteins and their annotated locations for NP_851832.2

    Status: VALIDATED

    Source sequence(s)
    AK085670, BX469932, BY121187, CD802657
    Consensus CDS
    CCDS30515.1
    UniProtKB/Swiss-Prot
    Q8C3J9, Q8K014, Q9QZA0
    Related
    ENSMUSP00000033739.5, ENSMUST00000033739.5
    Conserved Domains (1) summary
    cl00012
    Location:61296
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162759818..162811006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)