prps1b phosphoribosyl pyrophosphate synthetase 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prps1bprovided by ZNC
Official Full Name: phosphoribosyl pyrophosphate synthetase 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4011
See related: Ensembl:ENSDARG00000037506 AllianceGenome:ZFIN:ZDB-GENE-030131-4011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc64g03; im:6909503; wu:fc64g03; zgc:153331
Summary: Predicted to enable ATP binding activity and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to act upstream of or within nucleobase-containing small molecule metabolic process and phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; eye; notochord; semicircular canal; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to several human genes including PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (12076802..12106627, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (11770788..11800613, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G44812 (e-PCR)
- UniSTS:105614

fc64g03.x1 (e-PCR)
- UniSTS:203972

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribose phosphate diphosphokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribose phosphate diphosphokinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ribose phosphate diphosphokinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribose-phosphate pyrophosphokinase 1

NP_001070036.1

EC 2.7.6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076568.2 → NP_001070036.1 ribose-phosphate pyrophosphokinase 1

See identical proteins and their annotated locations for NP_001070036.1

Status: VALIDATED

Source sequence(s)

BC153527, BX957302, EH476966

UniProtKB/TrEMBL

A0A2R8Q3X4, F6PFP6, Q08CA5

Related

ENSDARP00000054618.5, ENSDART00000054619.6

Conserved Domains (3) summary

COG0462
Location:1 → 313

PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

pfam13793
Location:4 → 120

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

cl00309
Location:161 → 313

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain