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Tspan5 tetraspanin 5 [ Mus musculus (house mouse) ]

Gene ID: 56224, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan5provided by MGI
Official Full Name
tetraspanin 5provided by MGI
Primary source
MGI:MGI:1928096
See related
Ensembl:ENSMUSG00000028152 AllianceGenome:MGI:1928096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NET-4; Tm4sf9; 2810455A09Rik; 4930505M03Rik
Summary
Enables enzyme binding activity. Involved in protein maturation. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; heart; inner ear; limb; and physiological umbilical hernia. Orthologous to human TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 21.1), frontal lobe adult (RPKM 20.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H1; 3 64.42 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138447609..138610194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138741848..138904433)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09111 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1437.1 Neighboring gene STARR-seq mESC enhancer starr_09114 Neighboring gene RIKEN cDNA 4930425O10 gene Neighboring gene STARR-seq mESC enhancer starr_09115 Neighboring gene STARR-seq mESC enhancer starr_09116 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:138406051-138406234 Neighboring gene STARR-seq mESC enhancer starr_09117 Neighboring gene STARR-positive B cell enhancer ABC_E11223 Neighboring gene STARR-positive B cell enhancer mm9_chr3:138527106-138527407 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:138539885-138540140 Neighboring gene STARR-seq mESC enhancer starr_09124 Neighboring gene predicted gene, 54195 Neighboring gene RAP1, GTP-GDP dissociation stimulator 1 Neighboring gene synaptic nuclear envelope 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09125 Neighboring gene STARR-positive B cell enhancer ABC_E6140 Neighboring gene STARR-seq mESC enhancer starr_09128 Neighboring gene predicted gene 4862

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Colbert JD, et al. Proc Natl Acad Sci U S A, 2022 Oct 18. PMID 36215490, Free PMC Article
  2. Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse. García-Frigola C, et al. Mech Dev, 2001 Aug. PMID 11472858
  3. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. García-Frigola C, et al. Neuroreport, 2000 Sep 28. PMID 11043545
  4. New insights into the tetraspanin Tspan5 using novel monoclonal antibodies. Saint-Pol J, et al. J Biol Chem, 2017 Jun 9. PMID 28428248, Free PMC Article
  5. Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro. Zhou J, et al. Calcif Tissue Int, 2014 Sep. PMID 24935633, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation.
    Title: Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation.
  2. two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for ADAM10 interaction and exit from the endoplasmic reticulum. One of the anti-Tspan5 mAbs does not recognize Tspan5 associated with ADAM10, providing a convenient way to measure the fraction of Tspan5 not associated with ADAM10.
    Title: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.
  3. Tspan-5 and Tspan-10, are up-regulated during osteoclast differentiation and knockdown of their expression dramatically inhibits osteoclastogenesis
    Title: Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro.
  4. Up-regulated in pre-osteoclasts during cell differentiation.
    Title: Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis.
  5. The level of Tspan-5 expression might be important for distinct phases of neuronal maturation.
    Title: Tetraspanin-5 (Tm4sf9) mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic mice.
  6. This protein is expressed during brain development from embryonic stages to adulthood.
    Title: Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetraspanin-5
Names
tetraspan NET-4
tetraspanin Tspan-5
transmembrane 4 superfamily member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428885.1 → NP_001415814.1  tetraspanin-5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC114621

  2. NM_019571.6 → NP_062517.1  tetraspanin-5 isoform 1

    See identical proteins and their annotated locations for NP_062517.1

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC114621
    Consensus CDS
    CCDS17870.1
    UniProtKB/Swiss-Prot
    P62080
    UniProtKB/TrEMBL
    Q9CYT0
    Related
    ENSMUSP00000029800.3, ENSMUST00000029800.9
    Conserved Domains (2) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:15 → 257
    Tetraspannin; Tetraspanin family

RNA

  1. NR_121195.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC114621
    Related
    ENSMUST00000142890.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138447609..138610194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252697.1 → XP_030108557.1  tetraspanin-5 isoform X2

    UniProtKB/TrEMBL
    D3Z641
    Related
    ENSMUSP00000113230.2, ENSMUST00000119993.8
    Conserved Domains (1) summary
    cd03159
    Location:42 → 162
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_006501737.5 → XP_006501800.1  tetraspanin-5 isoform X2

    See identical proteins and their annotated locations for XP_006501800.1

    UniProtKB/TrEMBL
    D3Z641
    Conserved Domains (1) summary
    cd03159
    Location:42 → 162
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. XM_006501736.5 → XP_006501799.1  tetraspanin-5 isoform X1

    UniProtKB/TrEMBL
    Q9CYT0
    Conserved Domains (1) summary
    cd03159
    Location:156 → 276
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. XR_375551.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62080.1 GenPept UniProtKB/Swiss-Prot:P62080

Gene LinkOut

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