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Hdac7 histone deacetylase 7 [ Mus musculus (house mouse) ]

Gene ID: 56233, updated on 25-Nov-2021

Summary

Official Symbol
Hdac7provided by MGI
Official Full Name
histone deacetylase 7provided by MGI
Primary source
MGI:MGI:1891835
See related
Ensembl:ENSMUSG00000022475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik
Expression
Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues See more
Orthologs
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Genomic context

See Hdac7 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97690542..97742383, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97792661..97844502, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97623112..97662102, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene vitamin D (1,25-dihydroxyvitamin D3) receptor Neighboring gene predicted gene, 52171

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell-cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization TAS
Traceable Author Statement
more info
PubMed 
involved_in histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of striated muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
histone deacetylase 7
Names
histone deacetylase 7A
NP_001191204.1
NP_001191205.1
NP_001191206.1
NP_001191207.1
NP_001191208.1
NP_001191209.1
NP_001191210.1
NP_001365900.1
NP_062518.2
XP_006521268.1
XP_006521270.1
XP_006521271.1
XP_006521272.1
XP_006521273.1
XP_030104529.1
XP_036015418.1
XP_036015419.1
XP_036015420.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204275.1NP_001191204.1  histone deacetylase 7 isoform 1

    See identical proteins and their annotated locations for NP_001191204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57006.1
    UniProtKB/Swiss-Prot
    Q8C2B3
    Related
    ENSMUSP00000112110.3, ENSMUST00000116409.9
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  2. NM_001204276.1NP_001191205.1  histone deacetylase 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57005.1
    UniProtKB/Swiss-Prot
    Q8C2B3
    Related
    ENSMUSP00000113380.2, ENSMUST00000118294.8
    Conserved Domains (1) summary
    cd10008
    Location:515890
    HDAC7; Histone deacetylase 7
  3. NM_001204277.1NP_001191206.1  histone deacetylase 7 isoform 3

    See identical proteins and their annotated locations for NP_001191206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK044287, BB648696
    Consensus CDS
    CCDS57007.1
    UniProtKB/Swiss-Prot
    Q8C2B3
    Related
    ENSMUSP00000078766.8, ENSMUST00000079838.14
    Conserved Domains (1) summary
    cd10008
    Location:513888
    HDAC7; Histone deacetylase 7
  4. NM_001204278.1NP_001191207.1  histone deacetylase 7 isoform 5

    See identical proteins and their annotated locations for NP_001191207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57004.1
    UniProtKB/Swiss-Prot
    Q8C2B3
    Related
    ENSMUSP00000112109.3, ENSMUST00000116408.9
    Conserved Domains (1) summary
    cd10008
    Location:485860
    HDAC7; Histone deacetylase 7
  5. NM_001204279.1NP_001191208.1  histone deacetylase 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57001.1
    UniProtKB/TrEMBL
    E9PXW1
    Related
    ENSMUSP00000112459.2, ENSMUST00000119670.8
    Conserved Domains (1) summary
    cd10008
    Location:461836
    HDAC7; Histone deacetylase 7
  6. NM_001204280.1NP_001191209.1  histone deacetylase 7 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57003.1
    UniProtKB/TrEMBL
    E9PXW8
    Related
    ENSMUSP00000112446.2, ENSMUST00000120683.8
    Conserved Domains (1) summary
    cl17011
    Location:485812
    Arginase_HDAC; Arginase-like and histone-like hydrolases
  7. NM_001204281.1NP_001191210.1  histone deacetylase 7 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57002.1
    UniProtKB/TrEMBL
    E9PX62
    Related
    ENSMUSP00000112641.2, ENSMUST00000121514.8
    Conserved Domains (1) summary
    cd10008
    Location:420795
    HDAC7; Histone deacetylase 7
  8. NM_001378971.1NP_001365900.1  histone deacetylase 7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158787
    Conserved Domains (2) summary
    cd10008
    Location:544919
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:122525
    PHA03247; large tegument protein UL36; Provisional
  9. NM_019572.3NP_062518.2  histone deacetylase 7 isoform 4

    See identical proteins and their annotated locations for NP_062518.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK044287, BB648696, BC057332
    Consensus CDS
    CCDS37188.1
    UniProtKB/Swiss-Prot
    Q8C2B3
    Related
    ENSMUSP00000085744.6, ENSMUST00000088402.12
    Conserved Domains (1) summary
    cd10008
    Location:507882
    HDAC7; Histone deacetylase 7

RNA

  1. NR_166212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158787

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97690542..97742383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159526.1XP_036015419.1  histone deacetylase 7 isoform X4

    Conserved Domains (2) summary
    cd10008
    Location:500875
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:122499
    PHA03247; large tegument protein UL36; Provisional
  2. XM_030248669.2XP_030104529.1  histone deacetylase 7 isoform X3

    Conserved Domains (2) summary
    cd10008
    Location:511886
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:20492
    PHA03247; large tegument protein UL36; Provisional
  3. XM_006521210.4XP_006521273.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521273.1

    UniProtKB/Swiss-Prot
    Q8C2B3
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  4. XM_036159527.1XP_036015420.1  histone deacetylase 7 isoform X5

    Conserved Domains (1) summary
    cd10008
    Location:96471
    HDAC7; Histone deacetylase 7
  5. XM_006521208.5XP_006521271.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521271.1

    UniProtKB/Swiss-Prot
    Q8C2B3
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  6. XM_006521205.3XP_006521268.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521268.1

    UniProtKB/Swiss-Prot
    Q8C2B3
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  7. XM_006521209.3XP_006521272.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521272.1

    UniProtKB/Swiss-Prot
    Q8C2B3
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  8. XM_006521207.5XP_006521270.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521270.1

    UniProtKB/Swiss-Prot
    Q8C2B3
    Conserved Domains (2) summary
    cd10008
    Location:522897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100503
    PHA03247; large tegument protein UL36; Provisional
  9. XM_036159525.1XP_036015418.1  histone deacetylase 7 isoform X1

    Conserved Domains (2) summary
    cd10008
    Location:546921
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:124527
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_003951412.1 RNA Sequence

  2. XR_003951415.1 RNA Sequence

  3. XR_003951414.1 RNA Sequence

  4. XR_003951413.1 RNA Sequence

    Related
    ENSMUST00000228466.2
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